ID   2.3.1.240
DE   narbonolide synthase.
AN   pikromycin PKS.
CA   6 (S)-methylmalonyl-CoA + 12 H(+) + malonyl-CoA + 5 NADPH = 7 CO2 + 7 CoA
CA   + 2 H2O + 5 NADP(+) + narbonolide.
CC   -!- The product, narbonolide, contains a 14-membered ring and is an
CC       intermediate in the biosynthesis of narbonomycin and pikromycin in
CC       the bacterium Streptomyces venezuelae.
CC   -!- The enzyme also produces 10-deoxymethynolide (see EC 2.3.1.239).
CC   -!- The enzyme has 29 active sites arranged in four polypeptides (pikAI -
CC       pikAIV) with a loading domain, six extension modules and a terminal
CC       thioesterase domain.
CC   -!- Each extension module contains a ketosynthase (KS), keto reductase
CC       (KR), an acyltransferase (AT) and an acyl-carrier protein (ACP).
CC   -!- Not all active sites are used in the biosynthesis.
DR   Q9ZGI5, PIKA1_STRVZ;  Q9ZGI4, PIKA2_STRVZ;  Q9ZGI3, PIKA3_STRVZ;
DR   Q9ZGI2, PIKA4_STRVZ;
//