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ENZYME

ENZYME entry: EC 2.3.1.246

Accepted Name
3,5-dihydroxyphenylacetyl-CoA synthase
Reaction catalysed
4 H(+) + 4 malonyl-CoA <=> (3,5-dihydroxyphenyl)acetyl-CoA + 4 CO2 + 3 CoA + H2O
Comment(s)
The enzyme, characterized from the bacterium Amycolatopsis mediterranei, is involved in biosynthesis of the nonproteinogenic amino acid (S)-3,5-dihydroxyphenylglycine, a component of the vancomycin-type antibiotic balhimycin.
Cross-references
BRENDA2.3.1.246
EC2PDB2.3.1.246
ExplorEnz2.3.1.246
PRIAM enzyme-specific profiles2.3.1.246
KEGG Ligand Database for Enzyme Nomenclature2.3.1.246
IUBMB Enzyme Nomenclature2.3.1.246
IntEnz2.3.1.246
MEDLINEFind literature relating to 2.3.1.246
MetaCyc2.3.1.246
Rhea expert-curated reactions2.3.1.246
UniProtKB/Swiss-Prot
Q939X3, DPGA_AMYBAG4V4T4, DPGA_AMYORQ8KLK5, DPGA_STRTO

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