Accepted Name |
(4-hydroxyphenyl)alkanoate synthase
|
Reaction catalysed |
- 4-hydroxyphenyl-[4-hydroxyphenylalkanoate synthase] + 24 H(+) + 8 malonyl-CoA + 16 NADPH <=> 17-(4-hydroxyphenyl)heptadecanoyl-[4-hydroxyphenylalkanoate synthase] + 8 CO2 + 8 CoA + 8 H2O + 16 NADP(+)
- 4-hydroxyphenyl-[4-hydroxyphenylalkanoate synthase] + 27 H(+) + 9 malonyl-CoA + 18 NADPH <=> 19-(4-hydroxyphenyl)nonadecanoyl-[4-hydroxyphenylalkanoate synthase] + 9 CO2 + 9 CoA + 9 H2O + 18 NADP(+)
|
Comment(s) |
- The enzyme is part of the biosynthetic pathway of phenolphthiocerol,
a lipid that serves as a virulence factor of pathogenic mycobacteria.
- It catalyzes the elongation of 4-hydroxybenzoate that is loaded on
its acyl-carrier domain to form (4-hydroxyphenyl)alkanoate
intermediates.
- The enzyme adds either 8 or 9 malonyl-CoA units, resulting in
formation of 17-(4-hydroxyphenyl)heptadecanoate or
19-(4-hydroxyphenyl)nonadecanoate, respectively.
- As the enzyme lacks a thioesterase domain, the product remains loaded
on the acyl-carrier domain at the end of catalysis, and has to be
hydrolyzed by an as-yet unknown mechanism.
|
Cross-references |
BRENDA | 2.3.1.261 |
EC2PDB | 2.3.1.261 |
ExplorEnz | 2.3.1.261 |
PRIAM enzyme-specific profiles | 2.3.1.261 |
KEGG Ligand Database for Enzyme Nomenclature | 2.3.1.261 |
IUBMB Enzyme Nomenclature | 2.3.1.261 |
IntEnz | 2.3.1.261 |
MEDLINE | Find literature relating to 2.3.1.261 |
MetaCyc | 2.3.1.261 |
Rhea expert-curated reactions | 2.3.1.261 |
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