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ENZYME entry: EC 2.3.1.41

Accepted Name
Beta-ketoacyl-[acyl-carrier-protein] synthase I.
Alternative Name(s)
3-ketoacyl-acyl carrier protein synthase.
3-oxoacyl-[acyl-carrier-protein] synthase.
Acyl-malonyl acyl carrier protein-condensing enzyme.
Acyl-malonyl(acyl-carrier-protein)-condensing enzyme.
Beta-ketoacyl acyl carrier protein synthase.
Beta-ketoacyl synthetase.
Beta-ketoacyl-[acyl carrier protein] synthase.
Beta-ketoacyl-ACP synthase I.
Beta-ketoacyl-ACP synthetase.
Beta-ketoacyl-acyl carrier protein synthetase.
Beta-ketoacylsynthase.
Condensing enzyme.
Fatty acid condensing enzyme.
KAS I.
Reaction catalysed
Acyl-[acyl-carrier-protein] + malonyl-[acyl-carrier-protein] <=> 3-oxoacyl-[acyl-carrier-protein] + CO(2) + [acyl-carrier-protein]
Comment(s)
  • Responsible for the chain-elongation step of dissociated (type II) fatty-acid biosynthesis, i.e. the addition of two C atoms to the fatty-acid chain.
  • Escherichia coli mutants that lack this enzyme are deficient in unsaturated fatty acids.
  • Can use fatty acyl thioesters of ACP (C(2) to C(16)) as substrates, as well as fatty acyl thioesters of Co-A (C(4) to C(16)).
  • The substrate specificity is very similar to that of EC 2.3.1.179 with the exception that the latter enzyme is far more active with palmitoleoyl-ACP (C(16)-Delta(9)) as substrate, allowing the organism to regulate its fatty-acid composition with changes in temperature.
Cross-references
PROSITEPDOC00529
BRENDA2.3.1.41
EC2PDB2.3.1.41
ExplorEnz2.3.1.41
PRIAM enzyme-specific profiles2.3.1.41
KEGG Ligand Database for Enzyme Nomenclature2.3.1.41
IUBMB Enzyme Nomenclature2.3.1.41
IntEnz2.3.1.41
MEDLINEFind literature relating to 2.3.1.41
MetaCyc2.3.1.41
UniProtKB/Swiss-Prot
P39525, CEM1_YEAST;  P63455, FAB1_MYCBO;  Q9CBS7, FAB1_MYCLE;  
H8ESN0, FAB1_MYCTE;  P9WQD8, FAB1_MYCTO;  P9WQD9, FAB1_MYCTU;  
P63457, FAB2_MYCBO;  O69473, FAB2_MYCLE;  P9WQD6, FAB2_MYCTO;  
P9WQD7, FAB2_MYCTU;  P57193, FABB_BUCAI;  Q8KA28, FABB_BUCAP;  
Q89AY4, FABB_BUCBP;  P0A954, FABB_ECOL6;  P0A953, FABB_ECOLI;  
P43710, FABB_HAEIN;  P43098, FAS2_CANAX;  G8BAW7, FAS2_CANPC;  
P78615, FAS2_EMEND;  Q5B7V0, FAS2_EMENI;  Q765N2, FAS2_LACKL;  
P15368, FAS2_PENPA;  Q10289, FAS2_SCHPO;  P19097, FAS2_YEAST;  
Q71SP7, FAS_BOVIN;  P12276, FAS_CHICK;  P49327, FAS_HUMAN;  
P19096, FAS_MOUSE;  P12785, FAS_RAT;  P52410, KASC1_ARATH;  
P23902, KASC1_HORVU;  Q9C9P4, KASC2_ARATH;  Q8L3X9, KASM_ARATH;  
Q7TXK8, MSL7_MYCBO;  B2HIL7, MSL7_MYCMM;  Q0VCA7, OXSM_BOVIN;  
Q9NWU1, OXSM_HUMAN;  Q9D404, OXSM_MOUSE;  O94297, OXSM_SCHPO;  
Q7TXM0, PPSA_MYCBO;  P9WQE6, PPSA_MYCTO;  P9WQE7, PPSA_MYCTU;  
Q7TXL9, PPSB_MYCBO;  P9WQE4, PPSB_MYCTO;  P9WQE5, PPSB_MYCTU;  
Q7TXL8, PPSC_MYCBO;  P96202, PPSC_MYCTU;  Q7TXL7, PPSD_MYCBO;  
P9WQE2, PPSD_MYCTO;  P9WQE3, PPSD_MYCTU;  Q7TXL6, PPSE_MYCBO;  
P9WQE0, PPSE_MYCTO;  P9WQE1, PPSE_MYCTU;  

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All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.3.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.3.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-