ENZYME entry: EC 2.3.1.47

Accepted Name
8-amino-7-oxononanoate synthase.
Alternative Name(s)
7-KAP synthetase.
7-keto-8-aminopelargonic acid synthetase.
8-amino-7-ketopelargonate synthase.
AONS.
Reaction catalysed
Pimeloyl-[acyl-carrier protein] + L-alanine <=> 8-amino-7-oxononanoate + CO(2) + holo-[acyl-carrier protein]
Cofactor(s)
Pyridoxal 5'-phosphate.
Comment(s)
  • The enzyme catalyzes the decarboxylative condensation of L-alanine and pimeloyl-[acyl-carrier protein], a key step in the pathway for biotin biosynthesis.
  • Pimeloyl-CoA can be used with lower efficiency.
Cross-references
PROSITEPDOC00518
BRENDA2.3.1.47
EC2PDB2.3.1.47
ExplorEnz2.3.1.47
PRIAM enzyme-specific profiles2.3.1.47
KEGG Ligand Database for Enzyme Nomenclature2.3.1.47
IUBMB Enzyme Nomenclature2.3.1.47
IntEnz2.3.1.47
MEDLINEFind literature relating to 2.3.1.47
MetaCyc2.3.1.47
UniProtKB/Swiss-Prot
Q5SHZ8, BIKB_THET8;  A7Z4X1, BIOF1_BACMF;  O31777, BIOF1_BACSU;  
P9WQ86, BIOF1_MYCTO;  P9WQ87, BIOF1_MYCTU;  Q12F38, BIOF1_POLSJ;  
A7Z5B4, BIOF2_BACMF;  P53556, BIOF2_BACSU;  P9WQ84, BIOF2_MYCTO;  
P9WQ85, BIOF2_MYCTU;  Q12D74, BIOF2_POLSJ;  B0C205, BIOF_ACAM1;  
A1TTV0, BIOF_ACIAC;  A5FZN8, BIOF_ACICJ;  B7J3Y7, BIOF_ACIF2;  
B5ELF7, BIOF_ACIF5;  A0KIC7, BIOF_AERHH;  A4SPR6, BIOF_AERS4;  
Q0VMD1, BIOF_ALCBS;  B6ESC6, BIOF_ALISL;  Q0A5W2, BIOF_ALKEH;  
A6TU88, BIOF_ALKMQ;  A8MEX7, BIOF_ALKOO;  B8J637, BIOF_ANAD2;  
Q2IF62, BIOF_ANADE;  A7HG96, BIOF_ANADF;  B4UCB1, BIOF_ANASK;  
Q3M9A4, BIOF_ANAVT;  B7GHW7, BIOF_ANOFW;  O66875, BIOF_AQUAE;  
Q8GW43, BIOF_ARATH;  Q5NZF5, BIOF_AROAE;  A1K6Q1, BIOF_AZOSB;  
A0RIB9, BIOF_BACAH;  Q81MB0, BIOF_BACAN;  B7JLX2, BIOF_BACC0;  
Q731H9, BIOF_BACC1;  B7IWN1, BIOF_BACC2;  B7HAZ0, BIOF_BACC4;  
B7HNN4, BIOF_BACC7;  A7GSE1, BIOF_BACCN;  B9IWY0, BIOF_BACCQ;  
Q818X0, BIOF_BACCR;  Q635G4, BIOF_BACCZ;  Q9K625, BIOF_BACHD;  
Q6HE48, BIOF_BACHK;  Q65ML1, BIOF_BACLD;  Q8KZM9, BIOF_BACNA;  
A8FDG9, BIOF_BACP2;  A9VG56, BIOF_BACWK;  B2IH50, BIOF_BEII9;  
Q7WH76, BIOF_BORBR;  Q7W9I4, BIOF_BORPA;  A9HVE9, BIOF_BORPD;  
Q7VWP1, BIOF_BORPE;  Q89AK6, BIOF_BUCBP;  B1YNS0, BIOF_BURA4;  
Q1BT36, BIOF_BURCA;  B1JZD9, BIOF_BURCC;  A0KB03, BIOF_BURCH;  
B4E9L6, BIOF_BURCJ;  Q0BBD6, BIOF_BURCM;  Q39CE6, BIOF_BURL3;  
A9AE46, BIOF_BURM1;  A3MNG3, BIOF_BURM7;  A2S7R1, BIOF_BURM9;  
Q62MX1, BIOF_BURMA;  A1V819, BIOF_BURMS;  A3NQS3, BIOF_BURP0;  
Q3JWR6, BIOF_BURP1;  A3N522, BIOF_BURP6;  B2JKH6, BIOF_BURP8;  
B2SWS7, BIOF_BURPP;  Q63Y23, BIOF_BURPS;  Q2T1Q2, BIOF_BURTA;  
A4JIB5, BIOF_BURVG;  Q146K3, BIOF_BURXL;  B8GVE2, BIOF_CAUCN;  
Q9A7Z1, BIOF_CAUCR;  B0SZS9, BIOF_CAUSK;  B3PI88, BIOF_CELJU;  
B3QLR6, BIOF_CHLP8;  Q1QYD6, BIOF_CHRSD;  Q7NPW2, BIOF_CHRVO;  
A8AJ11, BIOF_CITK8;  A3DBD5, BIOF_CLOTH;  B5Y9Z4, BIOF_COPPD;  
A7MJ02, BIOF_CROS8;  Q1LS75, BIOF_CUPMC;  Q0KF88, BIOF_CUPNH;  
Q477A3, BIOF_CUPPJ;  B2AG98, BIOF_CUPTR;  B8HTV6, BIOF_CYAP4;  
B7KD70, BIOF_CYAP7;  B7K0L9, BIOF_CYAP8;  Q47C04, BIOF_DECAR;  
A9BV10, BIOF_DELAS;  B1I4F9, BIOF_DESAP;  B8J3V0, BIOF_DESDA;  
A8ZUS7, BIOF_DESOH;  A7ZJI5, BIOF_ECO24;  B7ULX3, BIOF_ECO27;  
B7MGN4, BIOF_ECO45;  B7LC58, BIOF_ECO55;  Q8X823, BIOF_ECO57;  
B5YRL5, BIOF_ECO5E;  B7NNK6, BIOF_ECO7I;  B7MQM9, BIOF_ECO81;  
B7M748, BIOF_ECO8A;  B1X7A6, BIOF_ECODH;  A7ZY32, BIOF_ECOHS;  
A1A918, BIOF_ECOK1;  Q0TJS2, BIOF_ECOL5;  Q8FJQ2, BIOF_ECOL6;  
B1IXJ2, BIOF_ECOLC;  P12998, BIOF_ECOLI;  B7NA75, BIOF_ECOLU;  
B6I7T0, BIOF_ECOSE;  B1LM67, BIOF_ECOSM;  Q1REF4, BIOF_ECOUT;  
A4W8B8, BIOF_ENT38;  B2VBT8, BIOF_ERWT9;  B7LJY7, BIOF_ESCF3;  
Q47829, BIOF_ESCVU;  B1YMC6, BIOF_EXIS2;  A7HMM1, BIOF_FERNB;  
B5EEV8, BIOF_GEOBB;  B9M8U3, BIOF_GEODF;  Q5KY23, BIOF_GEOKA;  
B3EAE0, BIOF_GEOLS;  Q39XE0, BIOF_GEOMG;  Q749W3, BIOF_GEOSL;  
A5G6I9, BIOF_GEOUR;  Q7NNL4, BIOF_GLOVI;  A9HJ57, BIOF_GLUDA;  
Q0BUV6, BIOF_GRABC;  Q7VL09, BIOF_HAEDU;  Q4QKR3, BIOF_HAEI8;  
A5UCE4, BIOF_HAEIE;  A5UJ44, BIOF_HAEIG;  P44422, BIOF_HAEIN;  
B8F713, BIOF_HAEPS;  Q2SBD5, BIOF_HAHCH;  A1WVM6, BIOF_HALHL;  
Q9ZLN3, BIOF_HELPJ;  O25320, BIOF_HELPY;  A4G5N9, BIOF_HERAR;  
A6SU64, BIOF_JANMA;  B5XZ74, BIOF_KLEP3;  A6T6L6, BIOF_KLEP7;  
B1Y500, BIOF_LEPCP;  P22806, BIOF_LYSSH;  A0L3L7, BIOF_MAGMM;  
Q2W3L2, BIOF_MAGSA;  A1U4B1, BIOF_MARHV;  Q0APZ9, BIOF_MARMM;  
A6W0Y0, BIOF_MARMS;  A6UWX3, BIOF_META3;  B7L0L2, BIOF_METC4;  
Q609V1, BIOF_METCA;  A9W106, BIOF_METEP;  Q1GZA7, BIOF_METFK;  
Q58694, BIOF_METJA;  B8IBW2, BIOF_METNO;  B1Z7Y8, BIOF_METPB;  
A2SD53, BIOF_METPP;  B1LYP9, BIOF_METRJ;  B0UKC8, BIOF_METS4;  
B8ERL9, BIOF_METSB;  A6UQL9, BIOF_METVS;  B0JQZ0, BIOF_MICAN;  
A0QHJ9, BIOF_MYCA1;  P0A4X5, BIOF_MYCBO;  A1KJ00, BIOF_MYCBP;  
A4T9L3, BIOF_MYCGI;  B8ZR84, BIOF_MYCLB;  P45487, BIOF_MYCLE;  
B2HQ90, BIOF_MYCMM;  Q740R7, BIOF_MYCPA;  A0QX65, BIOF_MYCS2;  
A3Q146, BIOF_MYCSJ;  A1UHM3, BIOF_MYCSK;  Q1B7F0, BIOF_MYCSS;  
A5U2S6, BIOF_MYCTA;  A5WMQ5, BIOF_MYCTF;  A0PP02, BIOF_MYCUA;  
A1T8U6, BIOF_MYCVP;  Q1DCV8, BIOF_MYXXD;  Q5F6R6, BIOF_NEIG1;  
B4RP93, BIOF_NEIG2;  A9M251, BIOF_NEIM0;  A1ITK1, BIOF_NEIMA;  
Q9K0U0, BIOF_NEIMB;  A1KVF6, BIOF_NEIMF;  Q0AE73, BIOF_NITEC;  
Q81ZZ4, BIOF_NITEU;  Q2Y9Y8, BIOF_NITMU;  Q3J9D6, BIOF_NITOC;  
B2J1W1, BIOF_NOSP7;  Q8YZT3, BIOF_NOSS1;  A7HP29, BIOF_PARL1;  
Q9CJU0, BIOF_PASMU;  Q6D3C0, BIOF_PECAS;  Q3A3Z8, BIOF_PELCD;  
A1AQT1, BIOF_PELPD;  A9BGL0, BIOF_PETMO;  B4RFX5, BIOF_PHEZH;  
Q7N6Q6, BIOF_PHOLL;  Q6LPR3, BIOF_PHOPR;  A1VUJ6, BIOF_POLNA;  
B4ESU4, BIOF_PROMH;  Q48CS2, BIOF_PSE14;  A6UYW1, BIOF_PSEA7;  
B7V486, BIOF_PSEA8;  Q02TR5, BIOF_PSEAB;  Q9I617, BIOF_PSEAE;  
Q1I3N7, BIOF_PSEE4;  Q4K4T3, BIOF_PSEF5;  A4XZR8, BIOF_PSEMY;  
A5VXF2, BIOF_PSEP1;  Q3K5P2, BIOF_PSEPF;  B0KJ54, BIOF_PSEPG;  
Q88QX1, BIOF_PSEPK;  B1JE54, BIOF_PSEPW;  Q88A97, BIOF_PSESM;  
Q4ZMA9, BIOF_PSEU2;  A4VR87, BIOF_PSEU5;  B2UBJ3, BIOF_RALPJ;  
Q8XZC3, BIOF_RALSO;  Q21FY4, BIOF_SACD2;  B5F073, BIOF_SALA4;  
A9MJE5, BIOF_SALAR;  Q57RG2, BIOF_SALCH;  B5FP62, BIOF_SALDC;  
B5QX66, BIOF_SALEP;  B5R762, BIOF_SALG2;  B4TC49, BIOF_SALHS;  
B4SZJ8, BIOF_SALNS;  Q5PG49, BIOF_SALPA;  A9MTI7, BIOF_SALPB;  
C0PWY3, BIOF_SALPC;  B5BC30, BIOF_SALPK;  B4TQU0, BIOF_SALSV;  
Q8Z892, BIOF_SALTI;  Q8ZQQ7, BIOF_SALTY;  P36570, BIOF_SERMA;  
A8GBC6, BIOF_SERP5;  B2TVF4, BIOF_SHIB3;  Q324B6, BIOF_SHIBS;  
Q32I45, BIOF_SHIDS;  Q0T6I4, BIOF_SHIF8;  Q83S45, BIOF_SHIFL;  
Q3Z408, BIOF_SHISS;  Q2NUJ6, BIOF_SODGM;  B4SM82, BIOF_STRM5;  
B2FLM5, BIOF_STRMK;  Q67N86, BIOF_SYMTH;  B1XL23, BIOF_SYNP2;  
P74770, BIOF_SYNY3;  B7ID58, BIOF_THEAB;  Q8DJ97, BIOF_THEEB;  
A6LMP4, BIOF_THEM4;  B0KC20, BIOF_THEP3;  B0K590, BIOF_THEPX;  
B5YFU5, BIOF_THEYD;  Q31E54, BIOF_THICR;  Q3SLX9, BIOF_THIDA;  
B8GTH6, BIOF_THISH;  Q73KM3, BIOF_TREDE;  Q119K2, BIOF_TRIEI;  
A7MX30, BIOF_VIBCB;  Q9KSZ3, BIOF_VIBCH;  Q5DZH9, BIOF_VIBF1;  
B5EUP9, BIOF_VIBFM;  Q87QN5, BIOF_VIBPA;  B7VH15, BIOF_VIBTL;  
Q8D8N0, BIOF_VIBVU;  Q7MLU9, BIOF_VIBVY;  Q8PQD8, BIOF_XANAC;  
Q3BYN0, BIOF_XANC5;  Q4UZN9, BIOF_XANC8;  B0RMR1, BIOF_XANCB;  
Q8PDF1, BIOF_XANCP;  Q2P8F2, BIOF_XANOM;  B2SS66, BIOF_XANOP;  
Q5H5R0, BIOF_XANOR;  B2I9H7, BIOF_XYLF2;  Q9PDM2, BIOF_XYLFA;  
B0U6J0, BIOF_XYLFM;  Q87DT2, BIOF_XYLFT;  A1JS67, BIOF_YERE8;  
A7FKM8, BIOF_YERP3;  Q1C946, BIOF_YERPA;  B2K8T1, BIOF_YERPB;  
Q7CH66, BIOF_YERPE;  A9R3C9, BIOF_YERPG;  Q1CFQ4, BIOF_YERPN;  
A4TNQ5, BIOF_YERPP;  Q66D66, BIOF_YERPS;  B1JSS3, BIOF_YERPY;  
C4LK80, BIOWF_CORK4;  Q6A6M4, BIOWF_PROAC;  D4H9Y2, BIOWF_PROAS;  

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