ENZYME entry: EC 2.3.1.82

Accepted Name
Aminoglycoside N(6')-acetyltransferase.
Alternative Name(s)
6'-aminoglycoside-N-acetyltransferase.
AAC(6').
Kanamycin 6'-N-acetyltransferase.
Reaction catalysed
Acetyl-CoA + kanamycin-B <=> CoA + N(6')-acetylkanamycin-B
Comment(s)
  • The antibiotics kanamycin A, kanamycin B, neomycin, gentamicin C(1a), gentamicin C(2), sisomicin and tobramycin are substrates.
  • The antibiotic paromomycin is not a substrate.
  • The 6-amino group of the purpurosamine ring is acetylated.
  • Formerly EC 2.3.1.55.
Cross-references
BRENDA2.3.1.82
EC2PDB2.3.1.82
ExplorEnz2.3.1.82
PRIAM enzyme-specific profiles2.3.1.82
KEGG Ligand Database for Enzyme Nomenclature2.3.1.82
IUBMB Enzyme Nomenclature2.3.1.82
IntEnz2.3.1.82
MEDLINEFind literature relating to 2.3.1.82
MetaCyc2.3.1.82
UniProtKB/Swiss-Prot
P10051, AAC6_CITDI;  P50858, AAC6_ENTAE;  P19650, AAC6_KLEPN;  
P20092, AAC6_SERMA;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.3.1.-
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