ID 2.3.1.86 DE fatty-acyl-CoA synthase system. AN fatty-acyl-CoA synthase. AN yeast fatty acid synthase. CA acetyl-CoA + 2n H(+) + n malonyl-CoA + 2n NADPH = a long-chain fatty CA acyl-CoA + n CO2 + n CoA + H2O + 2n NADP(+). CC -!- The enzyme from yeasts (Ascomycota and Basidiomycota) is a multi- CC functional protein complex composed of two subunits. CC -!- One subunit catalyzes the reactions EC 1.1.1.100 and EC 2.3.1.41, CC while the other subunit catalyzes the reactions of EC 2.3.1.38, CC EC 2.3.1.39, EC 4.2.1.59, EC 1.3.1.10 and EC 1.1.1.279. CC -!- The enzyme differs from the animal enzyme (EC 2.3.1.85) in that the CC enoyl reductase domain requires FMN as a cofactor, and the ultimate CC product is an acyl-CoA (usually palmitoyl-CoA) instead of a free CC fatty acid. DR Q8TGA2, AFLA_ASPPU ; Q8TGA1, AFLB_ASPPU ; Q5AV00, ATNF_EMENI ; DR Q5AV07, ATNM_EMENI ; P34731, FAS1_CANAX ; Q9UUG0, FAS1_SCHPO ; DR P34229, FAS1_YARLI ; P07149, FAS1_YEAST ; P43098, FAS2_CANAX ; DR G8BAW7, FAS2_CANPC ; P78615, FAS2_EMEND ; Q765N2, FAS2_LACKL ; DR P15368, FAS2_PENPA ; Q10289, FAS2_SCHPO ; P19097, FAS2_YEAST ; DR I1S489, GRA7_GIBZE ; I1R9A6, GRA9_GIBZE ; A7TUG9, HEXA_DOTSE ; DR M2YJJ3, HEXA_DOTSN ; M2XHU6, HEXB_DOTSN ; Q2TXF0, ORYA_ASPOR ; DR Q2TXG3, ORYB_ASPOR ; Q5B7V0, PKIB_EMENI ; A0A1U8QK63, PKIC_EMENI ; DR Q00681, STCJ_EMENI ; Q00706, STCK_EMENI ; Q92215, TOXC_COCCA ; DR S5NIA2, TOXH_COCCA ; //