ENZYME entry: EC 2.3.1.87

Accepted Name
Aralkylamine N-acetyltransferase.
Alternative Name(s)
AANAT.
Arylalkylamine N-acetyltransferase.
Melatonin rhythm enzyme.
Serotonin acetylase.
Serotonin acetyltransferase.
Serotonin N-acetyltransferase.
Reaction catalysed
Acetyl-CoA + a 2-arylethylamine <=> CoA + an N-acetyl-2-arylethylamine
Comment(s)
  • Narrow specificity toward 2-arylethylamines, including serotonin (5-hydroxytryptamine), tryptamine, 5-methoxytryptamine and phenylethylamine.
  • This is the penultimate enzyme in the production of melatonin (5-methoxy-N-acetyltryptamine) and controls its synthesis (cf. EC 2.1.1.4).
  • Differs from EC 2.3.1.5.
Cross-references
BRENDA2.3.1.87
EC2PDB2.3.1.87
ExplorEnz2.3.1.87
PRIAM enzyme-specific profiles2.3.1.87
KEGG Ligand Database for Enzyme Nomenclature2.3.1.87
IUBMB Enzyme Nomenclature2.3.1.87
IntEnz2.3.1.87
MEDLINEFind literature relating to 2.3.1.87
MetaCyc2.3.1.87
UniProtKB/Swiss-Prot
Q94521, DNAT_DROME;  O02785, SNAT_BOVIN;  P79774, SNAT_CHICK;  
Q16613, SNAT_HUMAN;  O97756, SNAT_MACMU;  Q9R0A9, SNAT_MESAU;  
O88816, SNAT_MOUSE;  Q5IS55, SNAT_PANTR;  Q64666, SNAT_RAT;  
Q29495, SNAT_SHEEP;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.3.1.-
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