To improve security and privacy, we are moving our web pages and services from HTTP to HTTPS.
To give users of web services time to transition to HTTPS, we will support separate HTTP and HTTPS services until the end of 2017.
From January 2018 most HTTP traffic will be automatically redirected to HTTPS. [more...]
View this page in https

ENZYME entry: EC 2.3.1.94

Accepted Name
6-deoxyerythronolide-B synthase.
Alternative Name(s)
6-deoxyerythronolide B synthase.
DEBS.
Deoxyerythronolide B synthase.
Erythronolide synthase.
Erythronolide-condensing enzyme.
Reaction catalysed
Propanoyl-CoA + 6 (2S)-methylmalonyl-CoA + 6 NADPH <=> 6-deoxyerythronolide B + 7 CoA + 6 CO(2) + H(2)O + 6 NADP(+)
Comment(s)
  • The product, 6-deoxyerythronolide B, contains a 14-membered lactone ring and is an intermediate in the biosynthesis of erythromycin antibiotics.
  • Biosynthesis of 6-deoxyerythronolide B requires 28 active sites that are precisely arranged along three large polypeptides, denoted DEBS1, -2 and -3.
  • The polyketide product is synthesized by the processive action of a loading didomain, six extension modules and a terminal thioesterase domain.
  • Each extension module contains a minimum of a ketosynthase (KS), an acyltransferase (AT) and an acyl-carrier protein (ACP).
  • The KS domain both accepts the growing polyketide chain from the previous module and catalyzes the subsequent decarboxylative condensation between this substrate and an ACP-bound methylmalonyl extender unit, introduce by the AT domain.
  • This combined effort gives rise to a new polyketide intermediate that has been extended by two carbon atoms.
Cross-references
BRENDA2.3.1.94
EC2PDB2.3.1.94
ExplorEnz2.3.1.94
PRIAM enzyme-specific profiles2.3.1.94
KEGG Ligand Database for Enzyme Nomenclature2.3.1.94
IUBMB Enzyme Nomenclature2.3.1.94
IntEnz2.3.1.94
MEDLINEFind literature relating to 2.3.1.94
MetaCyc2.3.1.94
UniProtKB/Swiss-Prot
Q03131, ERYA1_SACER;  Q03132, ERYA2_SACER;  Q03133, ERYA3_SACER;  

View entry in original ENZYME format
View entry in raw text format (no links)

All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.3.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.3.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-