ENZYME entry: EC 2.3.2.13

Accepted Name
Protein-glutamine gamma-glutamyltransferase.
Alternative Name(s)
Fibrinoligase.
Glutaminylpeptide gamma-glutamyltransferase.
Polyamine transglutaminase.
TGase.
Transglutaminase.
Reaction catalysed
Protein glutamine + alkylamine <=> protein N(5)-alkylglutamine + NH(3)
Cofactor(s)
Calcium.
Comment(s)
The gamma-carboxymide groups of peptide-bound glutamine residues act as acyl donors, and the 6-amino-groups of protein- and peptide-bound lysine residues act as acceptors, to give intra- and inter-molecular N(6)-(5-glutamyl)lysine crosslinks.
Cross-references
PROSITEPDOC00473
BRENDA2.3.2.13
EC2PDB2.3.2.13
ExplorEnz2.3.2.13
PRIAM enzyme-specific profiles2.3.2.13
KEGG Ligand Database for Enzyme Nomenclature2.3.2.13
IUBMB Enzyme Nomenclature2.3.2.13
IntEnz2.3.2.13
MEDLINEFind literature relating to 2.3.2.13
MetaCyc2.3.2.13
UniProtKB/Swiss-Prot
P52183, ANNU_SCHAM;  P12260, F13A_BOVIN;  P00488, F13A_HUMAN;  
Q8BH61, F13A_MOUSE;  O08619, F13A_RAT;  Q8GR90, TGAS_STRCJ;  
P81453, TGAS_STRMB;  C3P6X0, TGL_BACAA;  C3LI29, TGL_BACAC;  
A0RHX9, TGL_BACAH;  Q81MS1, TGL_BACAN;  B7JKT7, TGL_BACC0;  
B7IVK0, TGL_BACC2;  C1EPX7, TGL_BACC3;  B7H6V0, TGL_BACC4;  
B7HME8, TGL_BACC7;  A7GRZ1, TGL_BACCN;  B9IW43, TGL_BACCQ;  
Q819L3, TGL_BACCR;  Q635W3, TGL_BACCZ;  Q9K5W7, TGL_BACHD;  
Q6HEJ9, TGL_BACHK;  Q65FN2, TGL_BACLD;  A8FGT0, TGL_BACP2;  
P40746, TGL_BACSU;  A9VUC4, TGL_BACWK;  Q9GLK0, TGM1_CANFA;  
P22735, TGM1_HUMAN;  Q9JLF6, TGM1_MOUSE;  P22758, TGM1_RABIT;  
P23606, TGM1_RAT;  P51176, TGM2_BOVIN;  P08587, TGM2_CAVCU;  
Q01841, TGM2_CHICK;  P21980, TGM2_HUMAN;  P21981, TGM2_MOUSE;  
P52181, TGM2_PAGMA;  O95932, TGM3L_HUMAN;  A6QP57, TGM3_BOVIN;  
Q08188, TGM3_HUMAN;  Q08189, TGM3_MOUSE;  D4A5U3, TGM3_RAT;  
P49221, TGM4_HUMAN;  Q8BZH1, TGM4_MOUSE;  Q99041, TGM4_RAT;  
O43548, TGM5_HUMAN;  Q9D7I9, TGM5_MOUSE;  Q96PF1, TGM7_HUMAN;  
Q05187, TGMH_TACTR;  Q9HZX3, TGPA_PSEAE;  

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