ENZYME entry: EC 2.3.2.16

Accepted Name
Lipid II:glycine glycyltransferase.
Reaction catalysed
MurNAc-L-Ala-D-isoglutaminyl-L-Lys-D-Ala-D-Ala-diphospho-ditrans,octacis-undecaprenyl-GlcNAc + glycyl-tRNA(Gly) <=> MurNAc-L-Ala-D-isoglutaminyl-L-Lys-(N(6)-Gly)-D-Ala-D-Ala-diphospho-ditrans,octacis-undecaprenyl-GlcNAc + tRNA(Gly)
Comment(s)
  • This enzyme from Staphylococcus aureus catalyzes the transfer of glycine from a charged tRNA to MurNAc-L-Ala-D-isoglutaminyl-L-Lys-D- Ala-D-Ala-diphosphoundecaprenyl-GlcNAc (lipid II), attaching it to the N(6) of the L-lysine at position 3 of the pentapeptide.
  • This is the first step in the synthesis of the pentaglycine interpeptide bridge that is used in S.aureus for the crosslinking of different glycan strands to each other.
  • Four additional glycine residues are subsequently attached by EC 2.3.2.17 (FemA) and EC 2.3.2.18 (FemB).
Cross-references
BRENDA2.3.2.16
EC2PDB2.3.2.16
ExplorEnz2.3.2.16
PRIAM enzyme-specific profiles2.3.2.16
KEGG Ligand Database for Enzyme Nomenclature2.3.2.16
IUBMB Enzyme Nomenclature2.3.2.16
IntEnz2.3.2.16
MEDLINEFind literature relating to 2.3.2.16
MetaCyc2.3.2.16
UniProtKB/Swiss-Prot
Q2FEM9, FEMX_STAA3;  Q2FVZ4, FEMX_STAA8;  Q2YYN5, FEMX_STAAB;  
Q5HDU6, FEMX_STAAC;  Q7A2M4, FEMX_STAAM;  Q7A447, FEMX_STAAN;  
Q6GEH2, FEMX_STAAR;  Q6G760, FEMX_STAAS;  P0C1Q0, FEMX_STAAU;  
Q8NVA9, FEMX_STAAW;  Q5HLY6, FEMX_STAEQ;  Q8CNE9, FEMX_STAES;  
Q4L8C6, FEMX_STAHJ;  Q49ZI0, FEMX_STAS1;  

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