ID   2.3.2.17
DE   N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-(N(6)-glycyl)-D-alanyl-D-
DE   alanine-diphosphoundecaprenyl-N-acetylglucosamine:glycine
DE   glycyltransferase.
CA   beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-D-isoglutaminyl-L-Lys-(N(6)-Gly)-D-
CA   Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + 2 glycyl-
CA   tRNA(Gly) = 2 H(+) + MurNAc-L-Ala-D-isoglutaminyl-L-Lys-(N(6)-tri-Gly)-D-
CA   Ala-D-Ala-diphospho-di-trans,octa-cis-undecaprenyl-GlcNAc + 2 tRNA(Gly).
CC   -!- This enzyme catalyzes the successive transfer of two glycine moieties
CC       from charged tRNAs to MurNAc-L-Ala-D-isoglutaminyl-L-Lys-(N(6)-Gly)-
CC       D-Ala-D-Ala-diphospho-ditrans,octacis-undecaprenyl-GlcNAc, attaching
CC       them to a glycine residue previously attached by EC 2.3.2.16 (FemX)
CC       to the N(6) of the L-lysine at position 3 of the pentapeptide.
CC   -!- This is the second step in the synthesis of the pentaglycine
CC       interpeptide bridge that is used by Staphylococcus aureus for the
CC       cross-linking of different glycan strands to each other.
CC   -!- The next step is catalyzed by EC 2.3.2.18 (FemB).
CC   -!- This enzyme is essential for methicillin resistance.
DR   Q2FYR2, FEMA_STAA8 ;  Q2YXZ5, FEMA_STAAB ;  Q5HG45, FEMA_STAAC ;
DR   Q99UA7, FEMA_STAAM ;  Q7A5R3, FEMA_STAAN ;  Q6GH31, FEMA_STAAR ;
DR   Q6G9I5, FEMA_STAAS ;  P0A0A5, FEMA_STAAU ;  P0A0A4, FEMA_STAAW ;
DR   P95734, FEMA_STAEP ;  Q5HPG6, FEMA_STAEQ ;  Q8CPA9, FEMA_STAES ;
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