ENZYME entry: EC 2.3.2.18
| Accepted Name |
|---|
| N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-(N(6)-triglycine)-D-alanyl-
D-alanine-diphosphoundecaprenyl-N-acetylglucosamine:glycine
glycyltransferase.
|
| Reaction catalysed |
|---|
| N-acetylmuramoyl-L-alanyl-D-isoglutaminyl-L-lysyl-(N(6)-triglycyl)-D-alanyl-D-alanine-diphosphoundecaprenyl-N-acetylglucosamine + 2 glycyl-tRNA <=> N-acetylmuramoyl-L-alanyl-D-isoglutaminyl-L-lysyl-(N(6)-pentaglycyl)-D-alanyl-D-alanine-diphosphoundecaprenyl-N-acetylglucosamine + 2 tRNA |
| Comment(s) |
|---|
- This Staphylococcus aureus enzyme catalyzes the successive transfer
of two glycine moieties from charged tRNAs to N-acetylmuramoyl-L-
alanyl-D-isoglutaminyl-L-lysyl-(N(6)-triglycyl)-D-alanyl-D-alanine-
diphosphoundecaprenyl-N-acetylglucosamine, attaching them to the
three glycine molecules that were previously attached to the N(6) of
the L-lysine at position 3 of the pentapeptide by EC 2.3.2.16 (FemX)
and EC 2.3.2.17 (FemA).
- This is the last step in the synthesis of the pentaglycine
interpeptide bridge that is used in this organism for the
crosslinking of different glycan strands to each other.
|
| Cross-references |
|---|
| BRENDA | 2.3.2.18 |
| EC2PDB | 2.3.2.18 |
| ExplorEnz | 2.3.2.18 |
| PRIAM enzyme-specific profiles | 2.3.2.18 |
| KEGG Ligand Database for Enzyme Nomenclature | 2.3.2.18 |
| IUBMB Enzyme Nomenclature | 2.3.2.18 |
| IntEnz | 2.3.2.18 |
| MEDLINE | Find literature relating to 2.3.2.18 |
| MetaCyc | 2.3.2.18 |
| UniProtKB/Swiss-Prot |
| Q2FYR1, FEMB_STAA8; | Q2YXZ4, FEMB_STAAB; | Q5HG44, FEMB_STAAC; |
| P0A0A6, FEMB_STAAM; | P0A0A7, FEMB_STAAN; | Q6GH30, FEMB_STAAR; |
| Q6G9I4, FEMB_STAAS; | P0A0A8, FEMB_STAAU; | Q8NWU0, FEMB_STAAW; |
| P95735, FEMB_STAEP; | Q5HPG5, FEMB_STAEQ; | Q8CPA8, FEMB_STAES; |
|
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