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ENZYME

ENZYME entry: EC 2.3.2.18

Accepted Name
N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-(N(6)-triglycine)-D-alanyl- D-alanine-diphosphoundecaprenyl-N-acetylglucosamine:glycine glycyltransferase
Reaction catalysed
2 glycyl-tRNA(Gly) + MurNAc-L-Ala-D-isoglutaminyl-L-Lys-(N(6)-tri-Gly)-D-Ala-D-Ala-diphospho-di-trans,octa-cis-undecaprenyl-GlcNAc <=> 2 H(+) + MurNAc-L-Ala-D-isoglutaminyl-L-Lys-(N(6)-penta-Gly)-D-Ala-D-Ala-diphospho-di-trans,octa-cis-undecaprenyl-GlcNAc + 2 tRNA(Gly)
Comment(s)
  • This Staphylococcus aureus enzyme catalyzes the successive transfer of two glycine moieties from charged tRNAs to MurNAc-L-Ala-D- isoglutaminyl-L-Lys-(N(6)-tri-Gly)-D-Ala-D-Ala-diphospho- ditrans,octacis-undecaprenyl-GlcNAc, attaching them to the three glycine molecules that were previously attached to the N(6) of the L-lysine at position 3 of the pentapeptide by EC 2.3.2.16 (FemX) and EC 2.3.2.17 (FemA).
  • This is the last step in the synthesis of the pentaglycine interpeptide bridge that is used in this organism for the cross- linking of different glycan strands to each other.
Cross-references
BRENDA2.3.2.18
EC2PDB2.3.2.18
ExplorEnz2.3.2.18
PRIAM enzyme-specific profiles2.3.2.18
KEGG Ligand Database for Enzyme Nomenclature2.3.2.18
IUBMB Enzyme Nomenclature2.3.2.18
IntEnz2.3.2.18
MEDLINEFind literature relating to 2.3.2.18
MetaCyc2.3.2.18
Rhea expert-curated reactions2.3.2.18
UniProtKB/Swiss-Prot
Q2FYR1, FEMB_STAA8Q2YXZ4, FEMB_STAABQ5HG44, FEMB_STAAC
P0A0A6, FEMB_STAAMP0A0A7, FEMB_STAANQ6GH30, FEMB_STAAR
Q6G9I4, FEMB_STAASP0A0A8, FEMB_STAAUQ8NWU0, FEMB_STAAW
P95735, FEMB_STAEPQ5HPG5, FEMB_STAEQQ8CPA8, FEMB_STAES

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