ENZYME entry: EC 2.3.2.18

Accepted Name
N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-(N(6)-triglycine)-D-alanyl- D-alanine-diphosphoundecaprenyl-N-acetylglucosamine:glycine glycyltransferase.
Reaction catalysed
MurNAc-L-Ala-D-isoglutaminyl-L-Lys-(N(6)-tri-Gly)-D-Ala-D-Ala-diphospho-ditrans,octacis-undecaprenyl-GlcNAc + 2 glycyl-tRNA <=> MurNAc-L-Ala-D-isoglutaminyl-L-Lys-(N(6)-penta-Gly)-D-Ala-D-Ala-diphospho-ditrans,octacis-undecaprenyl-GlcNAc + 2 tRNA
Comment(s)
  • This Staphylococcus aureus enzyme catalyzes the successive transfer of two glycine moieties from charged tRNAs to MurNAc-L-Ala-D- isoglutaminyl-L-Lys-(N(6)-tri-Gly)-D-Ala-D-Ala-diphospho- ditrans,octacis-undecaprenyl-GlcNAc, attaching them to the three glycine molecules that were previously attached to the N(6) of the L-lysine at position 3 of the pentapeptide by EC 2.3.2.16 (FemX) and EC 2.3.2.17 (FemA).
  • This is the last step in the synthesis of the pentaglycine interpeptide bridge that is used in this organism for the crosslinking of different glycan strands to each other.
Cross-references
BRENDA2.3.2.18
EC2PDB2.3.2.18
ExplorEnz2.3.2.18
PRIAM enzyme-specific profiles2.3.2.18
KEGG Ligand Database for Enzyme Nomenclature2.3.2.18
IUBMB Enzyme Nomenclature2.3.2.18
IntEnz2.3.2.18
MEDLINEFind literature relating to 2.3.2.18
MetaCyc2.3.2.18
UniProtKB/Swiss-Prot
Q2FYR1, FEMB_STAA8;  Q2YXZ4, FEMB_STAAB;  Q5HG44, FEMB_STAAC;  
P0A0A6, FEMB_STAAM;  P0A0A7, FEMB_STAAN;  Q6GH30, FEMB_STAAR;  
Q6G9I4, FEMB_STAAS;  P0A0A8, FEMB_STAAU;  Q8NWU0, FEMB_STAAW;  
P95735, FEMB_STAEP;  Q5HPG5, FEMB_STAEQ;  Q8CPA8, FEMB_STAES;  

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