ENZYME entry: EC 2.3.2.21

Accepted Name
Cyclo(L-tyrosyl-L-tyrosyl) synthase.
Alternative Name(s)
Cyclodityrosine synthase.
Reaction catalysed
2 L-tyrosyl-tRNA(Tyr) <=> 2 tRNA(Tyr) + cyclo(L-tyrosyl-L-tyrosyl)
Comment(s)
  • The reaction proceeds following a ping-pong mechanism forming a covalent intermediate between an active site serine and the first L-tyrosine residue.
  • The protein, from the bacterium Mycobacterium tuberculosis, also forms small amounts of cyclo(L-tyrosyl-L-phenylalanyl).
Cross-references
BRENDA2.3.2.21
EC2PDB2.3.2.21
ExplorEnz2.3.2.21
PRIAM enzyme-specific profiles2.3.2.21
KEGG Ligand Database for Enzyme Nomenclature2.3.2.21
IUBMB Enzyme Nomenclature2.3.2.21
IntEnz2.3.2.21
MEDLINEFind literature relating to 2.3.2.21
MetaCyc2.3.2.21
UniProtKB/Swiss-Prot
P9WPF8, CDTS_MYCTO;  P9WPF9, CDTS_MYCTU;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.3.2.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.3.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-