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ENZYME entry: EC 2.3.2.22

Accepted Name
Cyclo(L-leucyl-L-leucyl) synthase.
Alternative Name(s)
Cyclodileucine synthase.
Reaction catalysed
2 L-leucyl-tRNA(Leu) <=> 2 tRNA(Leu) + cyclo(L-leucyl-L-leucyl)
Comment(s)
  • The reaction proceeds following a ping-pong mechanism forming a covalent intermediate between an active site serine and the first L-leucine residue.
  • The proteins from bacteria of the genus Bacillus also form small amounts of cyclo(L-phenylalanyl-L-leucyl) and cyclo(L-leucyl-L- methionyl).
Cross-references
BRENDA2.3.2.22
EC2PDB2.3.2.22
ExplorEnz2.3.2.22
PRIAM enzyme-specific profiles2.3.2.22
KEGG Ligand Database for Enzyme Nomenclature2.3.2.22
IUBMB Enzyme Nomenclature2.3.2.22
IntEnz2.3.2.22
MEDLINEFind literature relating to 2.3.2.22
MetaCyc2.3.2.22
UniProtKB/Swiss-Prot
Q65EX3, CDLS_BACLD;  O34351, CDLS_BACSU;  Q4JVS0, CDLS_CORJK;  
Q7N9M5, CDLS_PHOLL;  Q4L2X9, CDLS_STAHJ;  

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All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.3.2.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.3.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-