ENZYME entry: EC

Accepted Name
RING-type E3 ubiquitin transferase.
Alternative Name(s)
RING E3 ligase.
Ubiquitin transferase RING E3.
Reaction catalysed
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine <=> [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine
  • The RING domain of E3 ubiquitin transferase serves as a mediator bringing the ubiquitin-charged E2 ubiquitin-conjugating enzyme and the acceptor protein together to enable the direct transfer of ubiquitin through the formation of an isopeptide bond between the C-terminal glycine residue of ubiquitin an the epsilon-amino group of an L-lysine residue of the acceptor protein.
  • The RING-E3 domain does not form a catalytic thioester intermediate with ubiquitin (unlike the HECT domain, EC
  • RING-type ubiquitin transferases may occur as single-chain enzymes but also in dimeric forms or in multi-subunit assemblies.
  • Formerly EC and EC
PRIAM enzyme-specific profiles2.3.2.27
KEGG Ligand Database for Enzyme Nomenclature2.3.2.27
IUBMB Enzyme Nomenclature2.3.2.27
MEDLINEFind literature relating to
Q14258, TRI25_HUMAN;  Q61510, TRI25_MOUSE;  Q5UQ40, UBC4_MIMIV;  

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