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ENZYME entry: EC 2.3.2.27

Accepted Name
RING-type E3 ubiquitin transferase.
Alternative Name(s)
RING E3 ligase.
Ubiquitin transferase RING E3.
Reaction catalysed
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine <=> [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine
Comment(s)
  • The RING domain of E3 ubiquitin transferase serves as a mediator bringing the ubiquitin-charged E2 ubiquitin-conjugating enzyme and the acceptor protein together to enable the direct transfer of ubiquitin through the formation of an isopeptide bond between the C-terminal glycine residue of ubiquitin an the epsilon-amino group of an L-lysine residue of the acceptor protein.
  • The RING-E3 domain does not form a catalytic thioester intermediate with ubiquitin (unlike the HECT domain, EC 2.3.2.26).
  • RING-type ubiquitin transferases may occur as single-chain enzymes but also in dimeric forms or in multi-subunit assemblies.
  • Formerly EC 6.3.2.19 and EC 6.3.2.21.
Cross-references
BRENDA2.3.2.27
EC2PDB2.3.2.27
ExplorEnz2.3.2.27
PRIAM enzyme-specific profiles2.3.2.27
KEGG Ligand Database for Enzyme Nomenclature2.3.2.27
IUBMB Enzyme Nomenclature2.3.2.27
IntEnz2.3.2.27
MEDLINEFind literature relating to 2.3.2.27
MetaCyc2.3.2.27
UniProtKB/Swiss-Prot
Q8RXD3, AIP2_ARATH;  Q9UKV5, AMFR_HUMAN;  Q9R049, AMFR_MOUSE;  
P0CH01, AT21A_ARATH;  P0CH02, AT21B_ARATH;  P0CH03, AT21C_ARATH;  
P0C034, ATL10_ARATH;  Q84W40, ATL11_ARATH;  Q9SL78, ATL12_ARATH;  
Q940Q4, ATL13_ARATH;  Q9M0C3, ATL14_ARATH;  Q9SK92, ATL15_ARATH;  
Q9LSW9, ATL16_ARATH;  Q8LF65, ATL17_ARATH;  Q9SZL4, ATL18_ARATH;  
Q9C919, ATL19_ARATH;  P93823, ATL1_ARATH;  Q9C7E9, ATL20_ARATH;  
Q9SKK8, ATL22_ARATH;  Q8L9W3, ATL23_ARATH;  Q6NKR1, ATL28_ARATH;  
O49691, ATL29_ARATH;  Q8L9T5, ATL2_ARATH;  Q9FIR0, ATL30_ARATH;  
Q8LGA5, ATL31_ARATH;  Q8H7N9, ATL31_ORYSJ;  Q8W571, ATL32_ARATH;  
O80927, ATL33_ARATH;  Q9C7I1, ATL34_ARATH;  Q9M0R6, ATL35_ARATH;  
Q9M0R5, ATL36_ARATH;  Q9M0R4, ATL37_ARATH;  O64762, ATL38_ARATH;  
Q9M0R7, ATL39_ARATH;  Q9XF63, ATL3_ARATH;  Q9SLC4, ATL40_ARATH;  
Q9SLC3, ATL41_ARATH;  Q7XLY8, ATL41_ORYSJ;  Q5XF85, ATL42_ARATH;  
Q5EAE9, ATL43_ARATH;  O22755, ATL44_ARATH;  Q9ZT49, ATL45_ARATH;  
Q9FL07, ATL46_ARATH;  Q8GW38, ATL47_ARATH;  Q7X843, ATL48_ARATH;  
Q9ZV53, ATL49_ARATH;  Q9LY41, ATL4_ARATH;  Q9FHG8, ATL50_ARATH;  
Q9SRQ8, ATL51_ARATH;  Q9LF64, ATL52_ARATH;  P0C041, ATL53_ARATH;  
Q8LFY8, ATL54_ARATH;  Q9LX93, ATL55_ARATH;  Q9ZV51, ATL56_ARATH;  
Q9SJJ7, ATL57_ARATH;  Q570X5, ATL58_ARATH;  Q9SN27, ATL59_ARATH;  
Q9LZJ6, ATL5_ARATH;  P0C035, ATL60_ARATH;  Q9LUL6, ATL61_ARATH;  
Q5Z5F2, ATL61_ORYSJ;  Q9LJL6, ATL62_ARATH;  Q9LUZ9, ATL63_ARATH;  
O22255, ATL64_ARATH;  Q67YI6, ATL65_ARATH;  Q9SRM0, ATL66_ARATH;  
O82353, ATL67_ARATH;  Q9M313, ATL68_ARATH;  Q9FL42, ATL69_ARATH;  
Q8RXX9, ATL6_ARATH;  Q8RX29, ATL70_ARATH;  Q9FG21, ATL71_ARATH;  
Q9SG96, ATL72_ARATH;  Q9FLC6, ATL73_ARATH;  Q9LZV8, ATL74_ARATH;  
Q94BY6, ATL75_ARATH;  Q6NML0, ATL76_ARATH;  Q9LS99, ATL77_ARATH;  
Q6NQG7, ATL78_ARATH;  Q9FGJ6, ATL79_ARATH;  Q9SN28, ATL7_ARATH;  
Q9LM69, ATL80_ARATH;  Q9LQM2, ATL81_ARATH;  Q8LC69, ATL8_ARATH;  
O64763, ATL9_ARATH;  Q8GW10, BAH1L_ARATH;  Q9SRX9, BAH1_ARATH;  
A2XK56, BAHL1_ORYSI;  Q7XZZ3, BAHL1_ORYSJ;  B8B5U8, BAHL2_ORYSI;  
Q7XI73, BAHL2_ORYSJ;  Q21209, BARD1_CAEEL;  Q99728, BARD1_HUMAN;  
O70445, BARD1_MOUSE;  Q9QZH2, BARD1_RAT;  Q9LT17, BBR_ARATH;  
Q8L649, BB_ARATH;  Q8JHV9, BIR7A_XENLA;  A9ULZ2, BIR7B_XENLA;  
Q13490, BIRC2_HUMAN;  Q62210, BIRC2_MOUSE;  A1E2V0, BIRC3_CANLF;  
Q13489, BIRC3_HUMAN;  O08863, BIRC3_MOUSE;  Q9NR09, BIRC6_HUMAN;  
O88738, BIRC6_MOUSE;  Q96CA5, BIRC7_HUMAN;  A2AWP0, BIRC7_MOUSE;  
A9JTP3, BIRC7_XENTR;  O81851, BOI_ARATH;  Q7Z569, BRAP_HUMAN;  
Q99MP8, BRAP_MOUSE;  Q864U1, BRCA1_BOVIN;  Q95153, BRCA1_CANLF;  
Q6J6I8, BRCA1_GORGO;  P38398, BRCA1_HUMAN;  Q6J6I9, BRCA1_MACMU;  
P48754, BRCA1_MOUSE;  Q9GKK8, BRCA1_PANTR;  Q6J6J0, BRCA1_PONPY;  
O54952, BRCA1_RAT;  Q8RXD6, BRE1A_ARATH;  A2VDP1, BRE1A_BOVIN;  
Q5ZLS3, BRE1A_CHICK;  Q5VTR2, BRE1A_HUMAN;  Q5DTM8, BRE1A_MOUSE;  
A2XW69, BRE1A_ORYSI;  Q7XU27, BRE1A_ORYSJ;  Q9C895, BRE1B_ARATH;  
O75150, BRE1B_HUMAN;  Q4R7K7, BRE1B_MACFA;  Q3U319, BRE1B_MOUSE;  
A2ZAC2, BRE1B_ORYSI;  Q336R3, BRE1B_ORYSJ;  Q5RAU7, BRE1B_PONAB;  
Q8CJB9, BRE1B_RAT;  Q757D9, BRE1_ASHGO;  Q4WDD7, BRE1_ASPFU;  
Q2U9B0, BRE1_ASPOR;  Q60YN5, BRE1_CAEBR;  P34537, BRE1_CAEEL;  
Q5A4X0, BRE1_CANAL;  Q6FWF3, BRE1_CANGA;  P0CQ63, BRE1_CRYNB;  
P0CQ62, BRE1_CRYNJ;  Q6BWW6, BRE1_DEBHA;  Q86KL1, BRE1_DICDI;  
Q9VRP9, BRE1_DROME;  Q4I7N9, BRE1_GIBZE;  Q6CWM4, BRE1_KLULA;  
Q7S304, BRE1_NEUCR;  Q4P3X7, BRE1_USTMA;  Q6CF78, BRE1_YARLI;  
Q07457, BRE1_YEAST;  Q9FHE4, BRG1_ARATH;  F4IDI6, BRG2_ARATH;  
Q9LDD1, BRG3_ARATH;  Q1MTQ0, BRL1_SCHPO;  O74563, BRL2_SCHPO;  
B9DFV2, PQT3L_ARATH;  F4JP52, PQT3_ARATH;  Q14258, TRI25_HUMAN;  
Q61510, TRI25_MOUSE;  Q5UQ40, UBC4_MIMIV;  

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All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.3.2.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.3.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-