ENZYME entry: EC 2.3.2.5
| Accepted Name |
|---|
| Glutaminyl-peptide cyclotransferase.
|
| Alternative Name(s) |
|---|
| Glutaminyl cyclase. |
| Glutaminyl-tRNA cyclotransferase. |
| Reaction catalysed |
|---|
| L-glutaminyl-peptide <=> 5-oxoprolyl-peptide + NH(3) |
| Comment(s) |
|---|
- Involved in the formation of thyrotropin-releasing hormone and other
biologically active peptides containing N-terminal pyroglutamyl
residues.
- The enzyme from papaya also acts on glutaminyl-tRNA.
|
| Cross-references |
|---|
| BRENDA | 2.3.2.5 |
| EC2PDB | 2.3.2.5 |
| ExplorEnz | 2.3.2.5 |
| PRIAM enzyme-specific profiles | 2.3.2.5 |
| KEGG Ligand Database for Enzyme Nomenclature | 2.3.2.5 |
| IUBMB Enzyme Nomenclature | 2.3.2.5 |
| IntEnz | 2.3.2.5 |
| MEDLINE | Find literature relating to 2.3.2.5 |
| MetaCyc | 2.3.2.5 |
| UniProtKB/Swiss-Prot |
| Q0V8G3, QPCTL_BOVIN; | Q9NXS2, QPCTL_HUMAN; | Q4R942, QPCTL_MACFA; |
| Q8BH73, QPCTL_MOUSE; | Q84WV9, QPCT_ARATH; | A7ISW2, QPCT_BOIDE; |
| A7ISW1, QPCT_BOIIR; | Q9YIB5, QPCT_BOTJA; | Q28120, QPCT_BOVIN; |
| P0CV92, QPCT_CROAT; | Q54B14, QPCT_DICDI; | Q90YA8, QPCT_GLOBL; |
| Q16769, QPCT_HUMAN; | Q9CYK2, QPCT_MOUSE; |
|
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