ENZYME entry: EC 2.3.3.13

Accepted Name
2-isopropylmalate synthase.
Alternative Name(s)
3-carboxy-3-hydroxy-4-methylpentanoate 3-methyl-2-oxobutanoate-lyase (CoA-acetylating).
Alpha-IPM synthetase.
Alpha-isopropylmalate synthase.
Alpha-isopropylmalate synthetase.
Alpha-isopropylmalic synthetase.
Isopropylmalate synthase.
Isopropylmalate synthetase.
Reaction catalysed
Acetyl-CoA + 3-methyl-2-oxobutanoate + H(2)O <=> (2S)-2-isopropylmalate + CoA
Cofactor(s)
K(+).
Comment(s)
Formerly EC 4.1.3.12.
Cross-references
PROSITEPDOC00643 ; PDOC50991
BRENDA2.3.3.13
EC2PDB2.3.3.13
ExplorEnz2.3.3.13
PRIAM enzyme-specific profiles2.3.3.13
KEGG Ligand Database for Enzyme Nomenclature2.3.3.13
IUBMB Enzyme Nomenclature2.3.3.13
IntEnz2.3.3.13
MEDLINEFind literature relating to 2.3.3.13
MetaCyc2.3.3.13
UniProtKB/Swiss-Prot
Q9LPR4, LEU11_ARATH;  A8FFW5, LEU11_BACP2;  Q8RDK3, LEU11_CALS4;  
Q8XXP1, LEU11_RALSO;  Q31I16, LEU11_THICR;  Q9C550, LEU12_ARATH;  
A8FAK7, LEU12_BACP2;  Q8RCF9, LEU12_CALS4;  Q8XSZ5, LEU12_RALSO;  
Q31EF5, LEU12_THICR;  O04973, LEU1A_SOLPN;  O04974, LEU1B_SOLPN;  
A1TRT4, LEU1_ACIAC;  B9MA32, LEU1_ACIET;  C7M0E4, LEU1_ACIFD;  
A1W6T7, LEU1_ACISJ;  A0KGM9, LEU1_AERHH;  A4SR62, LEU1_AERS4;  
Q8UD63, LEU1_AGRFC;  Q0VLR3, LEU1_ALCBS;  B6ELK0, LEU1_ALISL;  
Q3MBA3, LEU1_ANAVT;  B7GH19, LEU1_ANOFW;  O67862, LEU1_AQUAE;  
A8ES07, LEU1_ARCB4;  O30020, LEU1_ARCFU;  Q5NXN2, LEU1_AROAE;  
A1R6V4, LEU1_ARTAT;  A0JX36, LEU1_ARTS2;  A1KBD3, LEU1_AZOSB;  
C1DE40, LEU1_AZOVD;  C3P4Z6, LEU1_BACAA;  C3L9Q7, LEU1_BACAC;  
A0RBL2, LEU1_BACAH;  Q81T68, LEU1_BACAN;  B7JFY5, LEU1_BACC0;  
Q73BA0, LEU1_BACC1;  C1EMA9, LEU1_BACC3;  A7GMU1, LEU1_BACCN;  
B9IUZ0, LEU1_BACCQ;  Q63DX8, LEU1_BACCZ;  Q9K8E8, LEU1_BACHD;  
Q6HLF3, LEU1_BACHK;  Q65GI8, LEU1_BACLD;  A7Z7B8, LEU1_BACMF;  
Q5WEN3, LEU1_BACSK;  P94565, LEU1_BACSU;  A9VLG7, LEU1_BACWK;  
B7GT76, LEU1_BIFLS;  Q7VQJ6, LEU1_BLOFL;  Q493R0, LEU1_BLOPB;  
A9HW07, LEU1_BORPD;  Q89GB0, LEU1_BRADU;  A5EP79, LEU1_BRASB;  
A4YZ76, LEU1_BRASO;  C0Z9C8, LEU1_BREBN;  Q8YIJ3, LEU1_BRUME;  
Q8FZC4, LEU1_BRUSU;  Q9ZEY8, LEU1_BUCAI;  O85063, LEU1_BUCAP;  
Q89A49, LEU1_BUCBP;  Q5WQ01, LEU1_BUCCC;  O85070, LEU1_BUCDN;  
Q9EVG4, LEU1_BUCML;  P58898, LEU1_BUCPS;  P48571, LEU1_BUCRP;  
O31287, LEU1_BUCTS;  Q9EVH6, LEU1_BUCUE;  Q9EVE3, LEU1_BUCUL;  
Q9EVH0, LEU1_BUCUM;  Q9EVI8, LEU1_BUCUN;  B1YTR7, LEU1_BURA4;  
Q1BV03, LEU1_BURCA;  B1JVQ1, LEU1_BURCC;  A0K933, LEU1_BURCH;  
B4E5N2, LEU1_BURCJ;  Q0BDB9, LEU1_BURCM;  Q39ED5, LEU1_BURL3;  
A9AJN4, LEU1_BURM1;  A3NT94, LEU1_BURP0;  Q3JUB9, LEU1_BURP1;  
A3N7K7, LEU1_BURP6;  Q63VP3, LEU1_BURPS;  A4JGE0, LEU1_BURVG;  
Q13WM0, LEU1_BURXL;  A7ZES2, LEU1_CAMC1;  A0RQK7, LEU1_CAMFF;  
A7I0N8, LEU1_CAMHC;  A8FP35, LEU1_CAMJ8;  A7H667, LEU1_CAMJD;  
Q9PLV9, LEU1_CAMJE;  A1W1X2, LEU1_CAMJJ;  Q5HS76, LEU1_CAMJR;  
Q3AEQ5, LEU1_CARHZ;  C7QJN7, LEU1_CATAD;  B8H607, LEU1_CAUCN;  
Q9A823, LEU1_CAUCR;  B0T0G9, LEU1_CAUSK;  Q7P0H2, LEU1_CHRVO;  
A8ALM5, LEU1_CITK8;  A5CRB9, LEU1_CLAM3;  B0RCQ8, LEU1_CLAMS;  
Q97MC5, LEU1_CLOAB;  B8I1T7, LEU1_CLOCE;  B9E371, LEU1_CLOK1;  
A5MZ76, LEU1_CLOK5;  E3PVH7, LEU1_CLOSD;  A3DF94, LEU1_CLOTH;  
Q8FU05, LEU1_COREF;  A4QAP0, LEU1_CORGB;  P42455, LEU1_CORGL;  
A7MIC5, LEU1_CROS8;  Q1LPX2, LEU1_CUPMC;  Q0KCT8, LEU1_CUPNH;  
Q473V1, LEU1_CUPPJ;  B2AHM5, LEU1_CUPTR;  B1WQQ4, LEU1_CYAA5;  
B7KJX8, LEU1_CYAP7;  B7JYP4, LEU1_CYAP8;  P85362, LEU1_CYCRE;  
Q47BI0, LEU1_DECAR;  Q9RUA9, LEU1_DEIRA;  B1I1Y1, LEU1_DESAP;  
Q24PE3, LEU1_DESHY;  C4XPA8, LEU1_DESMR;  A4J181, LEU1_DESRM;  
B8DM91, LEU1_DESVM;  B5YEF4, LEU1_DICT6;  B8E2W9, LEU1_DICTD;  
A7ZHG6, LEU1_ECO24;  B7UIC4, LEU1_ECO27;  B7MAJ9, LEU1_ECO45;  
B7LFU5, LEU1_ECO55;  Q8X9Z8, LEU1_ECO57;  B5YZB0, LEU1_ECO5E;  
B7NHI2, LEU1_ECO7I;  B7MNT2, LEU1_ECO81;  B7M119, LEU1_ECO8A;  
C4ZPZ7, LEU1_ECOBW;  A7ZW25, LEU1_ECOHS;  A1A7C2, LEU1_ECOK1;  
Q0TLR5, LEU1_ECOL5;  Q8FL75, LEU1_ECOL6;  B1IRA4, LEU1_ECOLC;  
P09151, LEU1_ECOLI;  B7N7U9, LEU1_ECOLU;  B6HZ24, LEU1_ECOSE;  
B1LG11, LEU1_ECOSM;  Q1RGC3, LEU1_ECOUT;  C5B7R4, LEU1_EDWI9;  
A4W6H9, LEU1_ENT38;  B2VDA7, LEU1_ERWT9;  B7LWE2, LEU1_ESCF3;  
A8L551, LEU1_FRASN;  Q5KWJ3, LEU1_GEOKA;  D3EBC1, LEU1_GEOS4;  
Q8RL85, LEU1_GEOSE;  C5D5M0, LEU1_GEOSW;  A4IRH8, LEU1_GEOTN;  
Q7NI93, LEU1_GLOVI;  Q4QLS4, LEU1_HAEI8;  A5UD85, LEU1_HAEIE;  
P43861, LEU1_HAEIN;  Q0I2G1, LEU1_HAES1;  B8CX21, LEU1_HALOH;  
Q7VH30, LEU1_HELHP;  B0TCR1, LEU1_HELMI;  D8J0Q1, LEU1_HERSS;  
B0USF6, LEU1_HISS2;  A8AB61, LEU1_IGNH4;  A6WDF2, LEU1_KINRD;  
B5Y1W2, LEU1_KLEP3;  A6T4L9, LEU1_KLEP7;  B2GHT7, LEU1_KOCRD;  
Q02141, LEU1_LACLA;  Q02YX5, LEU1_LACLS;  Q6AED3, LEU1_LEIXX;  
B1XYA8, LEU1_LEPCP;  Q72RL9, LEU1_LEPIC;  Q8F445, LEU1_LEPIN;  
Q92A28, LEU1_LISIN;  C1KWT1, LEU1_LISMC;  Q71Y35, LEU1_LISMF;  
B8DBU4, LEU1_LISMH;  Q8Y5R9, LEU1_LISMO;  A0AK92, LEU1_LISW6;  
B1HR98, LEU1_LYSSC;  A0LBW3, LEU1_MAGMM;  A6VSA9, LEU1_MARMS;  
Q8THA5, LEU1_METAC;  Q605K7, LEU1_METCA;  B3DX88, LEU1_METI4;  
Q58595, LEU1_METJA;  Q8TYB1, LEU1_METKA;  P58968, LEU1_METMA;  
B8IHS8, LEU1_METNO;  B1ZDN3, LEU1_METPB;  A2SHL8, LEU1_METPP;  
O27525, LEU1_METTH;  P94907, LEU1_MICAE;  B0JGK2, LEU1_MICAN;  
Q7TVV6, LEU1_MYCBO;  Q9CB76, LEU1_MYCLE;  P9WQB2, LEU1_MYCTO;  
P9WQB3, LEU1_MYCTU;  A0PVE6, LEU1_MYCUA;  Q5F8D4, LEU1_NEIG1;  
Q9JUK6, LEU1_NEIMA;  Q9JZG1, LEU1_NEIMB;  A1KTV6, LEU1_NEIMF;  
Q0AGN5, LEU1_NITEC;  Q820M0, LEU1_NITEU;  Q1QJV3, LEU1_NITHX;  
Q2YBW0, LEU1_NITMU;  Q3J877, LEU1_NITOC;  A6Q4V5, LEU1_NITSB;  
Q3SQ49, LEU1_NITWN;  Q5YVA5, LEU1_NOCFA;  P48575, LEU1_NOSS1;  
Q8EN67, LEU1_OCEIH;  B6JB87, LEU1_OLICO;  E1QWZ1, LEU1_OLSUV;  
A6LDN1, LEU1_PARD8;  A7HP03, LEU1_PARL1;  B2JDN6, LEU1_PARP8;  
B2SXZ9, LEU1_PARPJ;  Q9CJN5, LEU1_PASMU;  Q6D0G8, LEU1_PECAS;  
C6DEV8, LEU1_PECCP;  A5D4W0, LEU1_PELTS;  Q7N129, LEU1_PHOLL;  
Q6LV24, LEU1_PHOPR;  A1VN06, LEU1_POLNA;  B1XUJ3, LEU1_POLNS;  
Q12B47, LEU1_POLSJ;  A4SXR0, LEU1_POLSQ;  A3PDH0, LEU1_PROM0;  
A2C3L7, LEU1_PROM1;  A8G5D5, LEU1_PROM2;  A2C859, LEU1_PROM3;  
A9BB43, LEU1_PROM4;  A2BX52, LEU1_PROM5;  Q31AF9, LEU1_PROM9;  
Q7VBG1, LEU1_PROMA;  B4F194, LEU1_PROMH;  Q7TUV5, LEU1_PROMM;  
Q7V121, LEU1_PROMP;  A2BRP4, LEU1_PROMS;  Q46K01, LEU1_PROMT;  
Q48LY5, LEU1_PSE14;  Q15QR4, LEU1_PSEA6;  A6V0X2, LEU1_PSEA7;  
Q9HXK5, LEU1_PSEAE;  B8H8Q9, LEU1_PSECP;  Q1I5K2, LEU1_PSEE4;  
Q4K6V7, LEU1_PSEF5;  C3K1K7, LEU1_PSEFS;  A4XY24, LEU1_PSEMY;  
A5VZB6, LEU1_PSEP1;  Q3K7C3, LEU1_PSEPF;  B0KRD9, LEU1_PSEPG;  
Q88P28, LEU1_PSEPK;  B1JDI2, LEU1_PSEPW;  Q886Y1, LEU1_PSESM;  
Q4ZX14, LEU1_PSEU2;  A4VNV6, LEU1_PSEU5;  A1SRG8, LEU1_PSYIN;  
Q9UZ08, LEU1_PYRAB;  Q8ZW35, LEU1_PYRAE;  Q8U2A2, LEU1_PYRFU;  
B2UJY9, LEU1_RALPJ;  A9WML8, LEU1_RENSM;  Q1MDH6, LEU1_RHIL3;  
Q98HN3, LEU1_RHILO;  Q9X7L2, LEU1_RHIME;  Q7UI51, LEU1_RHOBA;  
Q21VZ1, LEU1_RHOFT;  Q2IUT4, LEU1_RHOP2;  Q07PI3, LEU1_RHOP5;  
Q6N858, LEU1_RHOPA;  Q212A9, LEU1_RHOPB;  Q138Z2, LEU1_RHOPS;  
B3QCX5, LEU1_RHOPT;  Q2RT17, LEU1_RHORT;  A1AWA1, LEU1_RUTMC;  
B5F7U9, LEU1_SALA4;  A9MQD8, LEU1_SALAR;  Q57TE6, LEU1_SALCH;  
B5FI58, LEU1_SALDC;  B5R2K9, LEU1_SALEP;  B5RGE4, LEU1_SALG2;  
B4TJ72, LEU1_SALHS;  B4SU36, LEU1_SALNS;  Q5PDG1, LEU1_SALPA;  
A9MZK0, LEU1_SALPB;  C0Q5H1, LEU1_SALPC;  B5BLB5, LEU1_SALPK;  
D5HB86, LEU1_SALRM;  B4TWW1, LEU1_SALSV;  Q8Z9I0, LEU1_SALTI;  
P15875, LEU1_SALTY;  O59736, LEU1_SCHPO;  A8G9R1, LEU1_SERP5;  
A1S2E0, LEU1_SHEAM;  B8E4K4, LEU1_SHEB2;  A3CZK5, LEU1_SHEB5;  
A6WIB5, LEU1_SHEB8;  A9KY13, LEU1_SHEB9;  Q12SE7, LEU1_SHEDO;  
Q07WG9, LEU1_SHEFN;  B0TQM0, LEU1_SHEHH;  A3QIP0, LEU1_SHELP;  
Q8E9N2, LEU1_SHEON;  A8H9A1, LEU1_SHEPA;  A4Y2M0, LEU1_SHEPC;  
B8CM39, LEU1_SHEPW;  A0L1R0, LEU1_SHESA;  A8FQ83, LEU1_SHESH;  
Q0HE65, LEU1_SHESM;  Q0HZT4, LEU1_SHESR;  A1REY0, LEU1_SHESW;  
B1KKZ4, LEU1_SHEWM;  B2U281, LEU1_SHIB3;  Q326G1, LEU1_SHIBS;  
Q32K20, LEU1_SHIDS;  Q0T8C4, LEU1_SHIF8;  Q83SP0, LEU1_SHIFL;  
Q3Z5T6, LEU1_SHISS;  Q2NVW3, LEU1_SODGM;  Q39891, LEU1_SOYBN;  
E1R5X1, LEU1_SPISS;  A7X4N1, LEU1_STAA1;  A6U3E2, LEU1_STAA2;  
Q2FF67, LEU1_STAA3;  Q2FWK3, LEU1_STAA8;  A5IUK3, LEU1_STAA9;  
Q2YUF2, LEU1_STAAB;  Q5HEE4, LEU1_STAAC;  A6QIQ3, LEU1_STAAE;  
P63476, LEU1_STAAM;  P63477, LEU1_STAAN;  Q6GF16, LEU1_STAAR;  
Q6G7Q1, LEU1_STAAS;  A8Z4W0, LEU1_STAAT;  P58899, LEU1_STAAW;  
B9DMJ6, LEU1_STACT;  Q5HMF9, LEU1_STAEQ;  Q8CNL3, LEU1_STAES;  
Q4L7U0, LEU1_STAHJ;  Q49Z12, LEU1_STAS1;  Q82BV3, LEU1_STRAW;  
O31046, LEU1_STRCO;  D3HCJ2, LEU1_STRG3;  B4SI67, LEU1_STRM5;  
B2FT78, LEU1_STRMK;  D2ATJ4, LEU1_STRRD;  Q97W36, LEU1_SULSO;  
Q974X3, LEU1_SULTO;  Q2LWJ3, LEU1_SYNAS;  B1XLQ9, LEU1_SYNP2;  
A5GM47, LEU1_SYNPW;  Q7U892, LEU1_SYNPX;  A5GRZ0, LEU1_SYNR3;  
Q0IBI3, LEU1_SYNS3;  Q3AYY2, LEU1_SYNS9;  Q3AIA2, LEU1_SYNSC;  
P48576, LEU1_SYNY3;  Q8DJ32, LEU1_THEEB;  Q47RM9, LEU1_THEFY;  
Q9WZ23, LEU1_THEMA;  B9KB95, LEU1_THENN;  A5IJM2, LEU1_THEP1;  
B1L8U2, LEU1_THESQ;  Q56216, LEU1_THETH;  Q3SHE7, LEU1_THIDA;  
C4LAV7, LEU1_TOLAT;  Q112U2, LEU1_TRIEI;  B1H0A7, LEU1_UNCTG;  
C5CYP2, LEU1_VARPS;  A1WNY5, LEU1_VEREI;  A5CWZ3, LEU1_VESOH;  
Q9KP83, LEU1_VIBCH;  C3LR32, LEU1_VIBCM;  Q5E856, LEU1_VIBF1;  
B5FGH4, LEU1_VIBFM;  Q87SS7, LEU1_VIBPA;  B7VIF2, LEU1_VIBTL;  
Q8DEE1, LEU1_VIBVU;  Q7MP77, LEU1_VIBVY;  Q7M9W4, LEU1_WOLSU;  
P58900, LEU1_XANAC;  Q3BPJ9, LEU1_XANC5;  Q4UYG1, LEU1_XANC8;  
B0RP28, LEU1_XANCB;  P58901, LEU1_XANCP;  Q2P761, LEU1_XANOM;  
B2SNG9, LEU1_XANOP;  Q5H4C6, LEU1_XANOR;  B2I596, LEU1_XYLF2;  
Q9PCG3, LEU1_XYLFA;  Q87CL8, LEU1_XYLFT;  P06208, LEU1_YEAST;  
A1JJH7, LEU1_YERE8;  A7FM84, LEU1_YERP3;  Q1C1Z6, LEU1_YERPA;  
B2K4C9, LEU1_YERPB;  Q8ZIG8, LEU1_YERPE;  A9R142, LEU1_YERPG;  
Q1CMP5, LEU1_YERPN;  A4TQA2, LEU1_YERPP;  Q66EM1, LEU1_YERPS;  
B1JK98, LEU1_YERPY;  Q12166, LEU9_YEAST;  

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