ENZYME entry: EC 2.3.3.14

Accepted Name
Homocitrate synthase.
Alternative Name(s)
2-hydroxybutane-1,2,4-tricarboxylate 2-oxoglutarate-lyase (CoA- acetylating).
Acetyl-coenzyme A:2-ketoglutarate C-acetyl transferase.
Homocitrate synthetase.
Reaction catalysed
Acetyl-CoA + H(2)O + 2-oxoglutarate <=> (R)-2-hydroxybutane-1,2,4-tricarboxylate + CoA
Comment(s)
  • Belongs in the alpha-aminoadipate pathway of lysine synthesis, along with EC 4.2.1.36.
  • Also acts with oxaloacetate as substrate, but more slowly.
  • Formerly EC 4.1.3.21.
Cross-references
PROSITEPDOC00643 ; PDOC50991
BRENDA2.3.3.14
EC2PDB2.3.3.14
ExplorEnz2.3.3.14
PRIAM enzyme-specific profiles2.3.3.14
KEGG Ligand Database for Enzyme Nomenclature2.3.3.14
IUBMB Enzyme Nomenclature2.3.3.14
IntEnz2.3.3.14
MEDLINEFind literature relating to 2.3.3.14
MetaCyc2.3.3.14
UniProtKB/Swiss-Prot
Q8TKQ6, AKSA_METAC;  Q57926, AKSA_METJA;  Q8TW28, AKSA_METKA;  
P58967, AKSA_METMA;  O27667, AKSA_METTH;  Q9V1J1, HOSA_PYRAB;  
O59390, HOSA_PYRHO;  C3N5A3, HOSA_SULIA;  C4KGW9, HOSA_SULIK;  
C3MPM7, HOSA_SULIL;  C3MYM1, HOSA_SULIM;  C3NHU6, HOSA_SULIN;  
C3NDV7, HOSA_SULIY;  Q97ZE0, HOSA_SULSO;  Q971S5, HOSA_SULTO;  
O87198, HOSC_THET2;  P48570, HOSC_YEAST;  O94225, HOSM_PENCW;  
Q9Y823, HOSM_SCHPO;  Q12726, HOSM_YARLI;  Q12122, HOSM_YEAST;  
Q44290, NIFV1_NOSS1;  P58637, NIFV2_NOSS1;  Q00853, NIFVA_CLOPA;  
Q00852, NIFVO_CLOPA;  P70728, NIFV_AZOBR;  P23122, NIFV_AZOCH;  
P05342, NIFV_AZOVI;  Q52070, NIFV_ENTAG;  Q47884, NIFV_FRAAL;  
P54610, NIFV_FRASP;  P05345, NIFV_KLEPN;  Q07179, NIFV_RHOCA;  
Q01181, NIFV_RHOSH;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.3.3.-
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