ENZYME entry: EC 2.3.3.8

Accepted Name
ATP citrate synthase.
Alternative Name(s)
Acetyl-CoA:oxaloacetate acetyltransferase (isomerizing; ADP- phosphorylating).
Adenosine triphosphate citrate lyase.
ATP citrate (pro-S)-lyase.
ATP-citrate (pro-S-)-lyase.
ATP-citric lyase.
ATP:citrate oxaloacetate-lyase ((pro-S)-CH(2)COO(-)->acetyl-CoA) (ATP- dephosphorylating).
Citrate cleavage enzyme.
Citrate-ATP lyase.
Citric cleavage enzyme.
Reaction catalysed
ADP + phosphate + acetyl-CoA + oxaloacetate <=> ATP + citrate + CoA
Comment(s)
  • The enzyme can be dissociated into components, two of which are identical with EC 4.1.3.34 and EC 6.2.1.18.
  • Formerly EC 4.1.3.8.
Cross-references
PROSITEPDOC00335
BRENDA2.3.3.8
EC2PDB2.3.3.8
ExplorEnz2.3.3.8
PRIAM enzyme-specific profiles2.3.3.8
KEGG Ligand Database for Enzyme Nomenclature2.3.3.8
IUBMB Enzyme Nomenclature2.3.3.8
IntEnz2.3.3.8
MEDLINEFind literature relating to 2.3.3.8
MetaCyc2.3.3.8
UniProtKB/Swiss-Prot
Q8X097, ACL1_NEUCR;  Q9P7W3, ACL1_SCHPO;  O93988, ACL1_SORMK;  
O13907, ACL2_SCHPO;  Q9SGY2, ACLA1_ARATH;  Q53JY8, ACLA1_ORYSJ;  
O22718, ACLA2_ARATH;  Q2QZ86, ACLA2_ORYSJ;  O80526, ACLA3_ARATH;  
Q2QNG7, ACLA3_ORYSJ;  Q9C522, ACLB1_ARATH;  Q93VT8, ACLB1_ORYSJ;  
Q9FGX1, ACLB2_ARATH;  Q32PF2, ACLY_BOVIN;  P53585, ACLY_CAEEL;  
Q54YA0, ACLY_DICDI;  P53396, ACLY_HUMAN;  Q91V92, ACLY_MOUSE;  
P16638, ACLY_RAT;  Q2TCH3, ACLY_SHEEP;  

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