ENZYME entry: EC 2.4.1.101

Accepted Name
Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase.
Alternative Name(s)
Alpha-1,3-mannosyl-glycoprotein beta-1,2-N-acetylglucosaminyltransferase.
GnTI.
N-acetylglucosaminyltransferase I.
N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase I.
UDP-N-acetylglucosaminyl:alpha-1,3-D-mannoside-beta-1,2-N- acetylglucosaminyltransferase I.
UDP-N-acetylglucosaminyl:alpha-3-D-mannoside beta-1,2-N- acetylglucosaminyltransferase I.
Uridine diphosphoacetylglucosamine-alpha-1,3-mannosylglycoprotein beta- 1,2-N-acetylglucosaminyltransferase.
Reaction catalysed
UDP-N-acetyl-D-glucosamine + 3-(alpha-D-mannosyl)-beta-D-mannosyl-R <=> UDP + 3-(2-(N-acetyl-beta-D-glucosaminyl)-alpha-D-mannosyl)-beta-D-mannosyl-R
Comment(s)
  • R represents the remainder of the N-linked oligosaccharide in the glycoprotein acceptor.
  • Note that this enzyme acts before N-acetylglucosaminyltransferases II (EC 2.4.1.143), III (EC 2.4.1.144), IV (EC 2.4.1.145), V (EC 2.4.1.155) and VI (EC 2.4.1.201).
  • Formerly EC 2.4.1.51.
Cross-references
BRENDA2.4.1.101
EC2PDB2.4.1.101
ExplorEnz2.4.1.101
PRIAM enzyme-specific profiles2.4.1.101
KEGG Ligand Database for Enzyme Nomenclature2.4.1.101
IUBMB Enzyme Nomenclature2.4.1.101
IntEnz2.4.1.101
MEDLINEFind literature relating to 2.4.1.101
MetaCyc2.4.1.101
UniProtKB/Swiss-Prot
Q9XGM8, MGAT1_ARATH;  Q11068, MGAT1_CAEEL;  P26572, MGAT1_HUMAN;  
P27808, MGAT1_MOUSE;  P27115, MGAT1_RABIT;  Q09325, MGAT1_RAT;  

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