ENZYME entry: EC 2.4.1.125

Accepted Name
Sucrose--1,6-alpha-glucan 3(6)-alpha-glucosyltransferase.
Alternative Name(s)
Water-soluble-glucan synthase.
Reaction catalysed
  • Sucrose + ((1->6)-alpha-D-glucosyl)(n) <=> D-fructose + ((1->6)-alpha-D-glucosyl)(n+1)
  • Sucrose + ((1->6)-alpha-D-glucosyl)(n) <=> D-fructose + (1->3)-alpha-D-glucosyl((1->6)-alpha-D-glucosyl)(n)
Comment(s)
  • The enzyme was characterized from the dental caries bacterium Streptococcus mutans.
  • It transfers glucosyl residues from sucrose to either the 6- or the 3-positions of glucose residues in glucans, producing a highly- branched extracellular D-glucan polymers that promote attachment of the bacteria to teeth.
  • Three types of the enzyme have been described; the insoluble polymers produced by GTF-I and GTF-SI contain 85% alpha(1->3) bonds and 15% alpha(1->6) bonds, while the soluble polymers produced by GTF-S contain only 30% of alpha(1->3) bonds and 70% alpha(1->6) bonds.
  • Cf. EC 2.4.1.5.
Cross-references
BRENDA2.4.1.125
EC2PDB2.4.1.125
ExplorEnz2.4.1.125
PRIAM enzyme-specific profiles2.4.1.125
KEGG Ligand Database for Enzyme Nomenclature2.4.1.125
IUBMB Enzyme Nomenclature2.4.1.125
IntEnz2.4.1.125
MEDLINEFind literature relating to 2.4.1.125
MetaCyc2.4.1.125

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