ENZYME entry: EC 2.4.1.129

Accepted Name
Peptidoglycan glycosyltransferase.
Alternative Name(s)
Bactoprenyldiphospho-N-acetylmuramoyl-(N-acetyl-D-glucosaminyl)- pentapeptide:peptidoglycan N-acetylmuramoyl-N-acetyl-D- glucosaminyltransferase.
Penicillin binding protein (3 or 1B).
Peptidoglycan TGase.
Peptidoglycan transglycosylase.
PG-II.
Reaction catalysed
(GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala))(n)-diphosphoundecaprenol + GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol <=> (GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala))(n+1)-diphosphoundecaprenol + undecaprenyl diphosphate
Comment(s)
  • The enzyme also works when the lysine residue is replaced by meso- 2,6-diaminoheptanedioate (meso-2,6-diaminopimelate, A2pm) combined with adjacent residues through its L-center, as it is in Gram- negative and some Gram-positive organisms.
  • The undecaprenol involved is ditrans,octacis-undecaprenol.
  • Involved in the synthesis of cell-wall peptidoglycan.
Cross-references
BRENDA2.4.1.129
EC2PDB2.4.1.129
ExplorEnz2.4.1.129
PRIAM enzyme-specific profiles2.4.1.129
KEGG Ligand Database for Enzyme Nomenclature2.4.1.129
IUBMB Enzyme Nomenclature2.4.1.129
IntEnz2.4.1.129
MEDLINEFind literature relating to 2.4.1.129
MetaCyc2.4.1.129
UniProtKB/Swiss-Prot
P57317, FTSI_BUCAI;  O85297, FTSI_BUCAP;  Q89AQ0, FTSI_BUCBP;  
B8H0A0, FTSI_CAUCN;  A2CI41, FTSI_CHLAT;  P0AD69, FTSI_ECO57;  
P0AD68, FTSI_ECOLI;  P45059, FTSI_HAEIN;  Q9MUV9, FTSI_MESVI;  
Q9TL36, FTSI_NEPOL;  P57296, PBPB_BUCAI;  Q89AR2, PBPB_BUCBP;  
P02919, PBPB_ECOLI;  P45345, PBPB_HAEIN;  A0R022, PBPB_MYCS2;  
Q9KUC0, PBPB_VIBCH;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.4.1.-
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