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ENZYME entry: EC 2.4.1.135

Accepted Name
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase.
Alternative Name(s)
Glucuronosyltransferase I.
Uridine diphosphate glucuronic acid:acceptor glucuronosyltransferase.
Reaction catalysed
UDP-alpha-D-glucuronate + [protein]-3-O-(beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-serine <=> UDP + [protein]-3-O-(beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-serine
Cofactor(s)
Mn(2+).
Comment(s)
Involved in the biosynthesis of the linkage region of glycosaminoglycan chains as part of proteoglycan biosynthesis (chondroitin, dermatan and heparan sulfates).
Cross-references
BRENDA2.4.1.135
EC2PDB2.4.1.135
ExplorEnz2.4.1.135
PRIAM enzyme-specific profiles2.4.1.135
KEGG Ligand Database for Enzyme Nomenclature2.4.1.135
IUBMB Enzyme Nomenclature2.4.1.135
IntEnz2.4.1.135
MEDLINEFind literature relating to 2.4.1.135
MetaCyc2.4.1.135
UniProtKB/Swiss-Prot
Q9VTG7, B3G2P_DROME;  Q9VLA1, B3G2S_DROME;  Q5CB03, B3GA1_CANLF;  
Q9P2W7, B3GA1_HUMAN;  Q9CW73, B3GA1_MOUSE;  Q5CB04, B3GA1_PANTR;  
O35789, B3GA1_RAT;  Q5CAZ6, B3GA2_CANLF;  Q9NPZ5, B3GA2_HUMAN;  
P59270, B3GA2_MOUSE;  Q9Z137, B3GA2_RAT;  Q9WU47, B3GA3_CRIGR;  
O94766, B3GA3_HUMAN;  P58158, B3GA3_MOUSE;  O97422, B3GI_DROME;  
Q09363, SQV8_CAEEL;  

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All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.4.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.4.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-