ENZYME

ENZYME entry: EC 2.4.1.143

Accepted Name

Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase.

Alternative Name(s)

Acetylglucosaminyltransferase II.

Alpha-1,6-mannosyl-glycoprotein beta-1,2-N-acetylglucosaminyltransferase.

GnTII.

N-acetylglucosaminyltransferase II.

N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase II.

UDP-GlcNAc:mannoside alpha-1-6 acetylglucosaminyltransferase.

Uridine diphosphoacetylglucosamine-alpha-1,6-mannosylglycoprotein beta-1- 2-N-acetylglucosaminyltransferase.

Uridine diphosphoacetylglucosamine-alpha-D-mannoside beta-1- 2-acetylglucosaminyltransferase.

Uridine diphosphoacetylglucosamine-mannoside alpha- 1->6-acetylglucosaminyltransferase.

Reaction catalysed

UDP-N-acetyl-D-glucosamine + 6-(alpha-D-mannosyl)-beta-D-mannosyl-R <=> UDP + 6-(2-(N-acetyl-beta-D-glucosaminyl)-alpha-D-mannosyl)-beta-D-mannosyl-R

Comment(s)

R represents the remainder of the N-linked oligosaccharide in the glycoprotein acceptor.
Note that this enzyme acts after N-acetylglucosaminyltransferase I (EC 2.4.1.101) but before N-acetylglucosaminyltransferases III (EC 2.4.1.144), IV (EC 2.4.1.145), V (EC 2.4.1.155) and VI (EC 2.4.1.201).
Formerly EC 2.4.1.51.

Cross-references

BRENDA

EC2PDB

ExplorEnz

PRIAM enzyme-specific profiles

KEGG Ligand Database for Enzyme Nomenclature

IUBMB Enzyme Nomenclature