ENZYME entry: EC 2.4.1.143

Accepted Name
Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase.
Alternative Name(s)
Acetylglucosaminyltransferase II.
Alpha-1,6-mannosyl-glycoprotein beta-1,2-N-acetylglucosaminyltransferase.
GnTII.
N-acetylglucosaminyltransferase II.
N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase II.
UDP-GlcNAc:mannoside alpha-1-6 acetylglucosaminyltransferase.
Uridine diphosphoacetylglucosamine-alpha-1,6-mannosylglycoprotein beta-1- 2-N-acetylglucosaminyltransferase.
Uridine diphosphoacetylglucosamine-alpha-D-mannoside beta-1- 2-acetylglucosaminyltransferase.
Uridine diphosphoacetylglucosamine-mannoside alpha- 1->6-acetylglucosaminyltransferase.
Reaction catalysed
UDP-N-acetyl-D-glucosamine + 6-(alpha-D-mannosyl)-beta-D-mannosyl-R <=> UDP + 6-(2-(N-acetyl-beta-D-glucosaminyl)-alpha-D-mannosyl)-beta-D-mannosyl-R
Comment(s)
  • R represents the remainder of the N-linked oligosaccharide in the glycoprotein acceptor.
  • Note that this enzyme acts after N-acetylglucosaminyltransferase I (EC 2.4.1.101) but before N-acetylglucosaminyltransferases III (EC 2.4.1.144), IV (EC 2.4.1.145), V (EC 2.4.1.155) and VI (EC 2.4.1.201).
  • Formerly EC 2.4.1.51.
Cross-references
BRENDA2.4.1.143
EC2PDB2.4.1.143
ExplorEnz2.4.1.143
PRIAM enzyme-specific profiles2.4.1.143
KEGG Ligand Database for Enzyme Nomenclature2.4.1.143
IUBMB Enzyme Nomenclature2.4.1.143
IntEnz2.4.1.143
MEDLINEFind literature relating to 2.4.1.143
MetaCyc2.4.1.143
UniProtKB/Swiss-Prot
Q10469, MGAT2_HUMAN;  Q921V5, MGAT2_MOUSE;  O19071, MGAT2_PIG;  
Q09326, MGAT2_RAT;  

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