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ENZYME entry: EC 2.4.1.145

Accepted Name
Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase.
Alternative Name(s)
Alpha-1,3-mannosylglycoprotein beta-1,4-N-acetylglucosaminyltransferase.
Beta-acetylglucosaminyltransferase IV.
GnTIV.
N-acetylglucosaminyltransferase IV.
N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase IV.
Uridine diphosphoacetylglucosamine-glycopeptide beta-4- acetylglucosaminyltransferase IV.
Reaction catalysed
UDP-N-acetyl-D-glucosamine + 3-(2-(N-acetyl-beta-D-glucosaminyl)-alpha-D-mannosyl)-beta-D-mannosyl-R <=> UDP + 3-(2,4-bis(N-acetyl-beta-D-glucosaminyl)-alpha-D-mannosyl)-beta-D-mannosyl-R
Comment(s)
  • R represents the remainder of the N-linked oligosaccharide in the glycoprotein acceptor.
  • The best acceptor for this enzyme is probably the same as that favored by EC 2.4.1.144.
  • Formerly EC 2.4.1.51.
Cross-references
BRENDA2.4.1.145
EC2PDB2.4.1.145
ExplorEnz2.4.1.145
PRIAM enzyme-specific profiles2.4.1.145
KEGG Ligand Database for Enzyme Nomenclature2.4.1.145
IUBMB Enzyme Nomenclature2.4.1.145
IntEnz2.4.1.145
MEDLINEFind literature relating to 2.4.1.145
MetaCyc2.4.1.145
UniProtKB/Swiss-Prot
O77836, MGT4A_BOVIN;  Q5F407, MGT4A_CHICK;  Q9UM21, MGT4A_HUMAN;  
Q4R854, MGT4A_MACFA;  Q812G0, MGT4A_MOUSE;  Q5REP8, MGT4A_PONAB;  
Q5M854, MGT4A_RAT;  Q6GQI7, MGT4A_XENLA;  A4IID1, MGT4A_XENTR;  
Q6GMK0, MGT4B_DANRE;  Q9UQ53, MGT4B_HUMAN;  Q812F8, MGT4B_MOUSE;  
Q9DGD1, MGT4C_CHICK;  Q5U3T0, MGT4C_DANRE;  Q9UBM8, MGT4C_HUMAN;  
Q4R4A8, MGT4C_MACFA;  Q9D306, MGT4C_MOUSE;  Q6ITT3, MGT4C_PIG;  

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All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.4.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.4.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-