Expasy logo

ENZYME

ENZYME entry: EC 2.4.1.147

Accepted Name
acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,3-N- acetylglucosaminyltransferase
Alternative Name(s)
Core 3beta-GlcNAc-transferase
O-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase III
Reaction catalysed
  • 3-O-[N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> 3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + H(+) + UDP
  • 3-O-[N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> 3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + H(+) + UDP
Comment(s)
  • The product of the enzyme is known as core 3, one of the eight core structures of mucin-type O-glycans.
  • O-Linked glycans are polysaccharides or oligosaccharides that are linked to a protein via the oxygen atom in the side chain of an L-serine or L-threonine residue.
Cross-references
BRENDA2.4.1.147
EC2PDB2.4.1.147
ExplorEnz2.4.1.147
PRIAM enzyme-specific profiles2.4.1.147
KEGG Ligand Database for Enzyme Nomenclature2.4.1.147
IUBMB Enzyme Nomenclature2.4.1.147
IntEnz2.4.1.147
MEDLINEFind literature relating to 2.4.1.147
MetaCyc2.4.1.147
Rhea expert-curated reactions2.4.1.147
UniProtKB/Swiss-Prot
Q6ZMB0, B3GN6_HUMANQ3USF0, B3GN6_MOUSE

View entry in original ENZYME format
View entry in raw text format (no links)
All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.4.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.4.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-