ENZYME entry: EC 2.4.1.147

Accepted Name
Acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,3-N- acetylglucosaminyltransferase.
Alternative Name(s)
Core 3-beta-GlcNAc-transferase.
O-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase III.
Reaction catalysed
UDP-N-acetyl-alpha-D-glucosamine + O(3)-(N-acetyl-alpha-D-galactosaminyl)-L-threonyl/L-seryl-[protein] <=> UDP + O(3)-(N-acetyl-beta-D-glucosaminyl-(1->3)-N-acetyl-alpha-D-galactosaminyl)-L-threonyl/L-seryl-[protein]
Comment(s)
  • The product of the enzyme is known as core 3, one of the eight core structures of mucin-type O-glycans.
  • O-linked glycans are polysaccharides or oligosaccharides that are linked to a protein via the oxygen atom in the side chain of an L-serine or L-threonine residue.
Cross-references
BRENDA2.4.1.147
EC2PDB2.4.1.147
ExplorEnz2.4.1.147
PRIAM enzyme-specific profiles2.4.1.147
KEGG Ligand Database for Enzyme Nomenclature2.4.1.147
IUBMB Enzyme Nomenclature2.4.1.147
IntEnz2.4.1.147
MEDLINEFind literature relating to 2.4.1.147
MetaCyc2.4.1.147
UniProtKB/Swiss-Prot
Q6ZMB0, B3GN6_HUMAN;  Q3USF0, B3GN6_MOUSE;  

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