ENZYME entry: EC 2.4.1.152

Accepted Name
4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase.
Alternative Name(s)
Galactoside 3-fucosyltransferase.
GDP-L-fucose:1,4-beta-D-galactosyl-N-acetyl-D-glucosaminyl-R 3-L- fucosyltransferase.
Guanosine diphosphofucose-glucoside alpha-1->3-fucosyltransferase.
Lewis-negative alpha-3-fucosyltransferase.
Plasma alpha-3-fucosyltransferase.
Reaction catalysed
GDP-beta-L-fucose + (1->4)-beta-D-galactosyl-N-acetyl-D-glucosaminyl-R <=> GDP + (1->4)-beta-D-galactosyl-(alpha-(1->3)-L-fucosyl)-N-acetyl-D-glucosaminyl-R
Comment(s)
  • Normally acts on a glycoconjugate where R (see CA line) is a glycoprotein or glycolipid.
  • This enzyme fucosylates on O-3 of an N-acetylglucosamine that carries a galactosyl group on O-4, unlike EC 2.4.1.65, which fucosylates on O-4 of an N-acetylglucosamine that carries a galactosyl group on O-3.
Cross-references
BRENDA2.4.1.152
EC2PDB2.4.1.152
ExplorEnz2.4.1.152
PRIAM enzyme-specific profiles2.4.1.152
KEGG Ligand Database for Enzyme Nomenclature2.4.1.152
IUBMB Enzyme Nomenclature2.4.1.152
IntEnz2.4.1.152
MEDLINEFind literature relating to 2.4.1.152
MetaCyc2.4.1.152

View entry in original ENZYME format
View entry in raw text format (no links)
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.4.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.4.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-