ENZYME entry: EC 2.4.1.174
| Accepted Name |
|---|
| Glucuronylgalactosylproteoglycan 4-beta-N-
acetylgalactosaminyltransferase.
|
| Alternative Name(s) |
|---|
| Glucuronylgalactosylproteoglycan beta-1,4-N-
acetylgalactosaminyltransferase. |
| N-acetylgalactosaminyltransferase I. |
| Uridine diphosphoacetylgalactosamine-chondroitin
acetylgalactosaminyltransferase I. |
| Reaction catalysed |
|---|
| UDP-N-acetyl-D-galactosamine + beta-D-glucuronyl-(1->3)-D-galactosyl-proteoglycan <=> UDP + N-acetyl-D-galactosaminyl-(1->4)-beta-D-glucuronyl-(1->3)-beta-D-galactosylproteoglycan |
| Comment(s) |
|---|
- Involved in the biosynthesis of chondroitin sulfate.
- Key enzyme activity for the initiation of chondroitin and dermatan
sulfates, transferring GalNAc to the GlcA-Gal-Gal-Xyl-Ser core.
|
| Cross-references |
|---|
| BRENDA | 2.4.1.174 |
| EC2PDB | 2.4.1.174 |
| ExplorEnz | 2.4.1.174 |
| PRIAM enzyme-specific profiles | 2.4.1.174 |
| KEGG Ligand Database for Enzyme Nomenclature | 2.4.1.174 |
| IUBMB Enzyme Nomenclature | 2.4.1.174 |
| IntEnz | 2.4.1.174 |
| MEDLINE | Find literature relating to 2.4.1.174 |
| MetaCyc | 2.4.1.174 |
| UniProtKB/Swiss-Prot |
|
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