ID   2.4.1.175
DE   glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-
DE   acetylgalactosaminyltransferase.
AN   chondroitin synthase.
AN   glucuronyl-N-acetylgalactosaminylproteoglycan beta-1,4-N-
AN   acetylgalactosaminyltransferase.
AN   N-acetylgalactosaminyltransferase II.
AN   UDP-N-acetyl-D-galactosamine:D-glucuronyl-N-acetyl-1,3-beta-D-
AN   galactosaminylproteoglycan beta-1,4-N-acetylgalactosaminyltransferase.
AN   uridine diphosphoacetylgalactosamine-chondroitin
AN   acetylgalactosaminyltransferase II.
CA   (1) 3-O-(beta-D-GlcA-(1->3)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-
CA   D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + UDP-N-
CA   acetyl-alpha-D-galactosamine = 3-O-(beta-D-GalNAc-(1->4)-beta-D-GlcA-
CA   (1->3)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-
CA   Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP.
CA   (2) 3-O-(beta-D-GlcA-(1->3)-[beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)](n)-
CA   beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-
CA   (1->4)-beta-D-Xyl)-L-seryl-[protein] + UDP-N-acetyl-alpha-D-galactosamine
CA   = 3-O-([beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)](n+1)-beta-D-GalNAc-
CA   (1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-
CA   Xyl)-L-seryl-[protein] + H(+) + UDP.
CC   -!- Involved in the biosynthesis of chondroitin sulfate.
CC   -!- The human form of this enzyme is a bifunctional glycosyltransferase,
CC       which also has the EC 2.4.1.226 activity required for the synthesis
CC       of the chondroitin sulfate disaccharide repeats.
CC   -!- Similar chondroitin synthase 'copolymerases' can be found in
CC       Pasteurella multocida and Escherichia coli.
DR   Q86X52, CHSS1_HUMAN;  Q6ZQ11, CHSS1_MOUSE;  Q8IZ52, CHSS2_HUMAN;
DR   Q6IQX7, CHSS2_MOUSE;  Q70JA7, CHSS3_HUMAN;  Q5DTK1, CHSS3_MOUSE;
DR   Q7Z1Z1, CHSSA_CAEEL;  P45895, CHSSB_CAEEL;  Q8L0V4, CHS_ECOLX  ;
DR   Q9CMP0, CHS_PASMU  ;
//