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ENZYME entry: EC 2.4.1.198

Accepted Name
Phosphatidylinositol N-acetylglucosaminyltransferase.
Alternative Name(s)
UDP-N-acetyl-D-glucosamine:phosphatidylinositol N-acetyl-D- glucosaminyltransferase.
Uridine diphosphoacetylglucosamine alpha-1,6-acetyl-D- glucosaminyltransferase.
Reaction catalysed
UDP-N-acetyl-D-glucosamine + 1-phosphatidyl-1D-myo-inositol <=> UDP + 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol
Comment(s)
  • Involved in the first step of glycosylphosphatidylinositol (GPI) anchor formation in all eukaryotes.
  • In mammalian cells, the enzyme is composed of at least five subunits (PIG-A, PIG-H, PIG-C, GPI1 and PIG-P).
  • PIG-A subunit is the catalytic subunit.
  • In some species, the long-chain acyl groups of the phosphatidyl group are partly replaced by long-chain alkyl or alk-1-enyl groups.
Cross-references
BRENDA2.4.1.198
EC2PDB2.4.1.198
ExplorEnz2.4.1.198
PRIAM enzyme-specific profiles2.4.1.198
KEGG Ligand Database for Enzyme Nomenclature2.4.1.198
IUBMB Enzyme Nomenclature2.4.1.198
IntEnz2.4.1.198
MEDLINEFind literature relating to 2.4.1.198
MetaCyc2.4.1.198
UniProtKB/Swiss-Prot
Q9Y7L7, GPI15_SCHPO;  P53961, GPI15_YEAST;  Q756D4, GPI19_ASHGO;  
Q04082, GPI19_YEAST;  P53306, GPI1_YEAST;  O59802, GPI2_SCHPO;  
P46961, GPI2_YEAST;  P87172, GPI3_SCHPO;  B3LKQ3, GPI3_YEAS1;  
B5VSZ6, GPI3_YEAS6;  A6ZW78, GPI3_YEAS7;  P32363, GPI3_YEAST;  
Q94BX4, PIGA_ARATH;  P37287, PIGA_HUMAN;  O64761, PIGC_ARATH;  
Q3ZBX1, PIGC_BOVIN;  Q54M40, PIGC_DICDI;  Q92535, PIGC_HUMAN;  
Q9CXR4, PIGC_MOUSE;  Q5PQQ4, PIGC_RAT;  Q32L89, PIGH_BOVIN;  
Q14442, PIGH_HUMAN;  Q5M9N4, PIGH_MOUSE;  O64792, PIGP_ARATH;  
P57054, PIGP_HUMAN;  Q9JHG1, PIGP_MOUSE;  Q5R946, PIGP_PONAB;  
Q9BRB3, PIGQ_HUMAN;  Q9QYT7, PIGQ_MOUSE;  

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