ENZYME entry: EC 2.4.1.212

Accepted Name
Hyaluronan synthase.
Alternative Name(s)
HAS.
Reaction catalysed
  • UDP-alpha-N-acetyl-D-glucosamine + beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-(nascent hyaluronan) <=> UDP + N-acetyl-beta-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-(nascent hyaluronan)
  • UDP-alpha-D-glucuronate + N-acetyl-beta-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-(nascent hyaluronan) <=> UDP + beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-(nascent hyaluronan)
Cofactor(s)
Magnesium.
Comment(s)
  • Adds GlcNAc to nascent hyaluronan when the non-reducing end is GlcA, but it adds GlcA when the non-reducing end is GlcNAc.
  • Highly specific for UDP-GlcNAc and UDP-GlcA; no copolymerization is observed if either is replaced by UDP-Glc, UDP-Gal, UDP-GalNAc or UDP-GalA.
Cross-references
BRENDA2.4.1.212
EC2PDB2.4.1.212
ExplorEnz2.4.1.212
PRIAM enzyme-specific profiles2.4.1.212
KEGG Ligand Database for Enzyme Nomenclature2.4.1.212
IUBMB Enzyme Nomenclature2.4.1.212
IntEnz2.4.1.212
MEDLINEFind literature relating to 2.4.1.212
MetaCyc2.4.1.212
UniProtKB/Swiss-Prot
Q92839, HAS1_HUMAN;  Q61647, HAS1_MOUSE;  P13563, HAS1_XENLA;  
B1WB39, HAS1_XENTR;  O97711, HAS2_BOVIN;  O57424, HAS2_CHICK;  
Q92819, HAS2_HUMAN;  P70312, HAS2_MOUSE;  O35776, HAS2_RAT;  
O57427, HAS2_XENLA;  O57425, HAS3_CHICK;  O00219, HAS3_HUMAN;  
O08650, HAS3_MOUSE;  O57426, HAS3_XENLA;  P0C0H1, HASA_STRP1;  
P0DB60, HASA_STRP3;  Q5X9A9, HASA_STRP6;  Q8NKX1, HASA_STRP8;  
P0DB61, HASA_STRPQ;  P0C0H0, HASA_STRPY;  Q7BLV3, HAS_PASMD;  

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