ENZYME entry: EC 2.4.1.221
| Accepted Name |
|---|
| Peptide-O-fucosyltransferase.
|
| Alternative Name(s) |
|---|
| GDP-fucose protein O-fucosyltransferase. |
| GDP-fucose:polypeptide fucosyltransferase. |
| GDP-L-fucose:polypeptide fucosyltransferase. |
| Reaction catalysed |
|---|
| Transfers an alpha-L-fucosyl residue from GDP-beta-L-fucose to the serine hydroxy group of a protein acceptor |
| Comment(s) |
|---|
- Involved in the biosynthesis of O-fucosylated epidermal growth factor
(EGF) and thrombospondin type 1 repeats.
- The attachment of O-linked fucose to serine or threonine occurs on
EGF domains within the sequence Cys-Xaa-Xaa-Gly-Gly-Ser/Thr-Cys.
|
| Cross-references |
|---|
| BRENDA | 2.4.1.221 |
| EC2PDB | 2.4.1.221 |
| ExplorEnz | 2.4.1.221 |
| PRIAM enzyme-specific profiles | 2.4.1.221 |
| KEGG Ligand Database for Enzyme Nomenclature | 2.4.1.221 |
| IUBMB Enzyme Nomenclature | 2.4.1.221 |
| IntEnz | 2.4.1.221 |
| MEDLINE | Find literature relating to 2.4.1.221 |
| MetaCyc | 2.4.1.221 |
| UniProtKB/Swiss-Prot |
| Q18014, OFUT1_CAEEL; | P83337, OFUT1_CRIGR; | Q9V6X7, OFUT1_DROME; |
| Q9H488, OFUT1_HUMAN; | Q91ZW2, OFUT1_MOUSE; | Q6EV69, OFUT1_PANTR; |
| Q6EV70, OFUT1_RAT; | Q8WR51, OFUT2_CAEEL; | Q9W589, OFUT2_DROME; |
| Q9Y2G5, OFUT2_HUMAN; | Q8VHI3, OFUT2_MOUSE; | Q6EV56, OFUT2_PANTR; |
|
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