ENZYME entry: EC 2.4.1.221

Accepted Name
Peptide-O-fucosyltransferase.
Alternative Name(s)
GDP-fucose protein O-fucosyltransferase.
GDP-fucose:polypeptide fucosyltransferase.
GDP-L-fucose:polypeptide fucosyltransferase.
Reaction catalysed
Transfers an alpha-L-fucosyl residue from GDP-beta-L-fucose to the serine hydroxy group of a protein acceptor
Comment(s)
  • Involved in the biosynthesis of O-fucosylated epidermal growth factor (EGF) and thrombospondin type 1 repeats.
  • The attachment of O-linked fucose to serine or threonine occurs on EGF domains within the sequence Cys-Xaa-Xaa-Gly-Gly-Ser/Thr-Cys.
Cross-references
BRENDA2.4.1.221
EC2PDB2.4.1.221
ExplorEnz2.4.1.221
PRIAM enzyme-specific profiles2.4.1.221
KEGG Ligand Database for Enzyme Nomenclature2.4.1.221
IUBMB Enzyme Nomenclature2.4.1.221
IntEnz2.4.1.221
MEDLINEFind literature relating to 2.4.1.221
MetaCyc2.4.1.221
UniProtKB/Swiss-Prot
Q18014, OFUT1_CAEEL;  P83337, OFUT1_CRIGR;  Q9V6X7, OFUT1_DROME;  
Q9H488, OFUT1_HUMAN;  Q91ZW2, OFUT1_MOUSE;  Q6EV69, OFUT1_PANTR;  
Q6EV70, OFUT1_RAT;  Q8WR51, OFUT2_CAEEL;  Q9W589, OFUT2_DROME;  
Q9Y2G5, OFUT2_HUMAN;  Q8VHI3, OFUT2_MOUSE;  Q6EV56, OFUT2_PANTR;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.4.1.-
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