ID 2.4.1.221 DE peptide-O-fucosyltransferase. AN GDP-fucose protein O-fucosyltransferase. CA (1) GDP-beta-L-fucose + L-seryl-[protein] = 3-O-(alpha-L-fucosyl)-L- CA seryl-[protein] + GDP + H(+). CA (2) GDP-beta-L-fucose + L-threonyl-[protein] = 3-O-(alpha-L-fucosyl)-L- CA threonyl-[protein] + GDP + H(+). CC -!- The enzyme, found in animals and plants, is involved in the CC biosynthesis of O-fucosylated proteins. CC -!- In EGF domains, the attachment of fucose to serine or threonine CC occurs within the sequence Cys-Xaa-Xaa-Gly-Gly-Ser/Thr-Cys. DR Q18014, OFUT1_CAEEL; P83337, OFUT1_CRIGR; Q9V6X7, OFUT1_DROME; DR Q9H488, OFUT1_HUMAN; Q91ZW2, OFUT1_MOUSE; Q6EV69, OFUT1_PANTR; DR Q6EV70, OFUT1_RAT ; Q8WR51, OFUT2_CAEEL; Q9W589, OFUT2_DROME; DR Q9Y2G5, OFUT2_HUMAN; Q8VHI3, OFUT2_MOUSE; Q6EV56, OFUT2_PANTR; DR A0A509AKB8, OFUT2_PLABA; W7K6N5, OFUT2_PLAFO; A5K6G1, OFUT2_PLAVS; DR S7WCF5, OFUT2_TOXGG; Q96301, SPY_ARATH ; //