ID   2.4.1.223
DE   Glucuronyl-galactosyl-proteoglycan 4-alpha-N-
DE   acetylglucosaminyltransferase.
AN   Alpha-1,4-N-acetylglucosaminyltransferase.
AN   Alpha-N-acetylglucosaminyltransferase I.
AN   Glucuronosylgalactosyl-proteoglycan 4-alpha-N-
AN   acetylglucosaminyltransferase.
CA   UDP-N-acetyl-D-glucosamine + beta-D-glucuronosyl-(1->3)-beta-D-
CA   galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl-proteoglycan =
CA   UDP + alpha-N-acetyl-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-
CA   beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl-
CA   proteoglycan.
CC   -!- Enzyme involved in the initiation of heparin and heparan sulfate
CC       synthesis, transferring GlcNAc to the (GlcA-Gal-Gal-Xyl-)Ser core.
CC   -!- Apparently products of both the human EXTL2 and EXTL3 genes can
CC       catalyze this reaction.
CC   -!- In Caenorhabditis elegans, the product of the rib-2 gene displays
CC       this activity as well as that of EC 2.4.1.224.
DR   O01705, EXT2_CAEEL ;  Q9XZ08, EXT3_DROME ;  Q9UBQ6, EXTL2_HUMAN;
DR   Q9ES89, EXTL2_MOUSE;  O43909, EXTL3_HUMAN;  Q9WVL6, EXTL3_MOUSE;
//