ID   2.4.1.226
DE   N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase.
AN   chondroitin glucuronyltransferase II.
CA   (1) 3-O-(beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-
CA   D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + UDP-alpha-D-glucuronate =
CA   3-O-(beta-D-GlcA-(1->3)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-
CA   Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP.
CA   (2) 3-O-([beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)](n)-beta-D-GalNAc-
CA   (1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-
CA   Xyl)-L-seryl-[protein] + UDP-alpha-D-glucuronate = 3-O-(beta-D-GlcA-
CA   (1->3)-[beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)](n)-beta-D-GalNAc-(1->4)-
CA   beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-
CA   seryl-[protein] + H(+) + UDP.
CC   -!- Involved in the biosynthesis of chondroitin and dermatan sulfate.
CC   -!- The human chondroitin synthetase is a bifunctional
CC       glycosyltransferase, which also has the EC 2.4.1.175 activity
CC       required for the synthesis of the chondroitin sulfate disaccharide
CC       repeats.
CC   -!- Similar chondroitin synthase 'copolymerases' can be found in
CC       Pasteurella multocida and Escherichia coli.
CC   -!- There is also another human protein with apparently only the 3-beta-
CC       glucuronosyltransferase activity.
DR   Q9P2E5, CHPF2_HUMAN;  Q86X52, CHSS1_HUMAN;  Q6ZQ11, CHSS1_MOUSE;
DR   Q8IZ52, CHSS2_HUMAN;  Q6IQX7, CHSS2_MOUSE;  Q70JA7, CHSS3_HUMAN;
DR   Q5DTK1, CHSS3_MOUSE;  Q7Z1Z1, CHSSA_CAEEL;  P45895, CHSSB_CAEEL;
DR   Q8L0V4, CHS_ECOLX  ;  Q9CMP0, CHS_PASMU  ;  Q7BLV3, HAS_PASMD  ;
//