ENZYME entry: EC 2.4.1.229

Accepted Name
[Skp1-protein]-hydroxyproline N-acetylglucosaminyltransferase.
Alternative Name(s)
Skp1-HyPro GlcNAc-transferase.
UDP-N-acetylglucosamine (GlcNAc):hydroxyproline polypeptide GlcNAc- transferase.
Reaction catalysed
UDP-N-acetyl-alpha-D-glucosamine + [Skp1-protein]-trans-4-hydroxy-L-proline <=> UDP + [Skp1-protein]-O-(N-acetyl-alpha-D-glucosaminyl)-trans-4-hydroxy-L-proline
Cofactor(s)
Divalent metal cation.
Comment(s)
  • Skp1 is a cytoplasmic and nuclear protein required for the ubiquitination of cell cycle regulatory proteins and transcriptional factors.
  • In Dictyostelium Skp1 is modified by the linear pentasaccharide Gal- alpha-1-6Gal-alpha-1-L-Fuc-alpha-1-2Gal-beta-1-3GlcNAc, which is attached to a hydroxyproline residue at position 143.
  • This enzyme catalyzes the first step in the building up of the pentasaccharide by attaching an N-acetylglucosaminyl group to the hydroxyproline residue.
Cross-references
BRENDA2.4.1.229
EC2PDB2.4.1.229
ExplorEnz2.4.1.229
PRIAM enzyme-specific profiles2.4.1.229
KEGG Ligand Database for Enzyme Nomenclature2.4.1.229
IUBMB Enzyme Nomenclature2.4.1.229
IntEnz2.4.1.229
MEDLINEFind literature relating to 2.4.1.229
MetaCyc2.4.1.229
UniProtKB/Swiss-Prot
Q8T1C6, GNT1_DICDI

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