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ENZYME entry: EC

Accepted Name
[Skp1-protein]-hydroxyproline N-acetylglucosaminyltransferase.
Alternative Name(s)
Skp1-HyPro GlcNAc-transferase.
UDP-N-acetylglucosamine (GlcNAc):hydroxyproline polypeptide GlcNAc- transferase.
Reaction catalysed
UDP-N-acetyl-alpha-D-glucosamine + [Skp1-protein]-trans-4-hydroxy-L-proline <=> UDP + [Skp1-protein]-O-(N-acetyl-alpha-D-glucosaminyl)-trans-4-hydroxy-L-proline
Divalent metal cation.
  • Skp1 is a cytoplasmic and nuclear protein required for the ubiquitination of cell cycle regulatory proteins and transcriptional factors.
  • In Dictyostelium Skp1 is modified by the linear pentasaccharide Gal- alpha-1-6Gal-alpha-1-L-Fuc-alpha-1-2Gal-beta-1-3GlcNAc, which is attached to a hydroxyproline residue at position 143.
  • This enzyme catalyzes the first step in the building up of the pentasaccharide by attaching an N-acetylglucosaminyl group to the hydroxyproline residue.
PRIAM enzyme-specific profiles2.4.1.229
KEGG Ligand Database for Enzyme Nomenclature2.4.1.229
IUBMB Enzyme Nomenclature2.4.1.229
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