ENZYME

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ENZYME entry: EC 2.4.1.244

Accepted Name

N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N- acetylgalactosaminyltransferase.

Alternative Name(s)

Beta-1,4-N-acetylgalactosaminyltransferase.

Beta-4GalNAc-T3.

Beta-4GalNAc-T4.

Reaction catalysed

UDP-N-acetyl-alpha-D-galactosamine + N-acetyl-beta-D-glucosaminyl group <=> UDP + N-acetyl-beta-D-galactosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl group

Comment(s)

The enzyme from human can transfer N-acetyl-D-galactosamine (GalNAc) to N-glycan and O-glycan substrates that have N-acetyl-D-glucosamine (GlcNAc) but not D-glucuronic acid (GlcUA) at their non-reducing end.
The N-acetyl-beta-D-glucosaminyl group is normally on a core oligosaccharide although benzyl glycosides have been used in enzyme- characterization experiments.
Some glycohormones, e.g. lutropin and thyrotropin contain the N-glycan structure containing the N-acetyl-beta-D-galactosaminyl- (1->4)-N-acetyl-beta-D-glucosaminyl group.

Cross-references

BRENDA

2.4.1.244

EC2PDB

2.4.1.244

ExplorEnz

2.4.1.244

PRIAM enzyme-specific profiles

2.4.1.244

KEGG Ligand Database for Enzyme Nomenclature

2.4.1.244

IUBMB Enzyme Nomenclature