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ENZYME entry: EC 2.4.1.244

Accepted Name
N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N- acetylgalactosaminyltransferase.
Alternative Name(s)
Beta-1,4-N-acetylgalactosaminyltransferase.
Beta-4GalNAc-T3.
Beta-4GalNAc-T4.
Reaction catalysed
UDP-N-acetyl-alpha-D-galactosamine + N-acetyl-beta-D-glucosaminyl group <=> UDP + N-acetyl-beta-D-galactosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl group
Comment(s)
  • The enzyme from human can transfer N-acetyl-D-galactosamine (GalNAc) to N-glycan and O-glycan substrates that have N-acetyl-D-glucosamine (GlcNAc) but not D-glucuronic acid (GlcUA) at their non-reducing end.
  • The N-acetyl-beta-D-glucosaminyl group is normally on a core oligosaccharide although benzyl glycosides have been used in enzyme- characterization experiments.
  • Some glycohormones, e.g. lutropin and thyrotropin contain the N-glycan structure containing the N-acetyl-beta-D-galactosaminyl- (1->4)-N-acetyl-beta-D-glucosaminyl group.
Cross-references
BRENDA2.4.1.244
EC2PDB2.4.1.244
ExplorEnz2.4.1.244
PRIAM enzyme-specific profiles2.4.1.244
KEGG Ligand Database for Enzyme Nomenclature2.4.1.244
IUBMB Enzyme Nomenclature2.4.1.244
IntEnz2.4.1.244
MEDLINEFind literature relating to 2.4.1.244
MetaCyc2.4.1.244
UniProtKB/Swiss-Prot
Q6L9W6, B4GN3_HUMAN;  Q6L8S8, B4GN3_MOUSE;  Q76KP1, B4GN4_HUMAN;  
Q766D5, B4GN4_MOUSE;  

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All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.4.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.4.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-