ENZYME entry: EC 2.4.1.246

Accepted Name
Mannosylfructose-phosphate synthase.
Alternative Name(s)
Mannosylfructose-6-phosphate synthase.
MFPS.
Reaction catalysed
GDP-mannose + D-fructose 6-phosphate <=> GDP + beta-D-fructofuranosyl-alpha-D-mannopyranoside 6(F)-phosphate
Cofactor(s)
Mn(2+) or Mg(2+).
Comment(s)
  • GDP-mannose can be replaced by ADP-mannose but with a concomitant decrease in activity.
  • The product of this reaction is dephosphorylated by EC 3.1.3.79 to form the non-reducing disaccharide mannosylfructose, which is the major endogenous osmolyte produced by several alpha-proteobacteria in response to osmotic stress.
  • The F in the product name is used to indicate that the fructose residue of sucrose carries the substituent.
Cross-references
BRENDA2.4.1.246
EC2PDB2.4.1.246
ExplorEnz2.4.1.246
PRIAM enzyme-specific profiles2.4.1.246
KEGG Ligand Database for Enzyme Nomenclature2.4.1.246
IUBMB Enzyme Nomenclature2.4.1.246
IntEnz2.4.1.246
MEDLINEFind literature relating to 2.4.1.246
MetaCyc2.4.1.246
UniProtKB/Swiss-Prot
A7TZT2, MFPS_AGRFC

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.4.1.-
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