ENZYME entry: EC 2.4.1.258

Accepted Name
Dolichyl-P-Man:Man(5)GlcNAc(2)-PP-dolichol alpha-1,3-mannosyltransferase.
Alternative Name(s)
Alg3 alpha-1,3-mannosyl transferase.
Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase.
Man(5)GlcNAc(2)-PP-Dol mannosyltransferase.
Reaction catalysed
Dolichyl beta-D-mannosyl phosphate + D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-(D-Man-alpha-(1->6))-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol <=> D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-(D-Man-alpha-(1->3)-D-Man-alpha-(1->6))-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl phosphate
Comment(s)
  • The formation of N-glycosidic linkages of glycoproteins involves the ordered assembly of the common Glc(3)Man(9)GlcNAc(2) core- oligosaccharide on the lipid carrier dolichyl diphosphate.
  • Early mannosylation steps occur on the cytoplasmic side of the endoplasmic reticulum with GDP-Man as donor, the final reactions from Man(5)GlcNAc(2)-PP-dolichyl to Man(9)Glc-NAc(2)-PP-dolichyl on the lumenal side use dolichyl beta-D-mannosyl phosphate.
  • The first step of this assembly pathway on the luminal side of the endoplasmic reticulum is catalyzed by ALG3.
  • Formerly EC 2.4.1.130.
Cross-references
BRENDA2.4.1.258
EC2PDB2.4.1.258
ExplorEnz2.4.1.258
PRIAM enzyme-specific profiles2.4.1.258
KEGG Ligand Database for Enzyme Nomenclature2.4.1.258
IUBMB Enzyme Nomenclature2.4.1.258
IntEnz2.4.1.258
MEDLINEFind literature relating to 2.4.1.258
MetaCyc2.4.1.258
UniProtKB/Swiss-Prot
O82244, ALG3_ARATH;  Q751K5, ALG3_ASHGO;  A1CBE6, ALG3_ASPCL;  
Q4WVG2, ALG3_ASPFU;  A2RA94, ALG3_ASPNC;  Q2U6A4, ALG3_ASPOR;  
Q6FXS2, ALG3_CANGA;  P0CN93, ALG3_CRYNB;  P0CN92, ALG3_CRYNJ;  
Q6BYY8, ALG3_DEBHA;  Q55F69, ALG3_DICDI;  Q92685, ALG3_HUMAN;  
Q6CMF1, ALG3_KLULA;  Q8K2A8, ALG3_MOUSE;  A1DDZ3, ALG3_NEOFI;  
Q9C1K8, ALG3_NEUCR;  Q0TVF9, ALG3_PHANO;  A5DJQ5, ALG3_PICGU;  
Q6DNA2, ALG3_PICPG;  A3LTB7, ALG3_PICST;  Q9Y7I4, ALG3_SCHPO;  
P38179, ALG3_YEAST;  

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