ENZYME entry: EC 2.4.1.259

Accepted Name
Dolichyl-P-Man:Man(6)GlcNAc(2)-PP-dolichol alpha-1,2-mannosyltransferase.
Alternative Name(s)
Dol-P-Man:Man(6)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase.
Reaction catalysed
Dolichyl beta-D-mannosyl phosphate + D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-(D-Man-alpha-(1->3)-D-Man-alpha-(1->6))-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol <=> D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-(D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-D-Man-alpha-(1->6))-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl phosphate
Comment(s)
  • The formation of N-glycosidic linkages of glycoproteins involves the ordered assembly of the common Glc(3)Man(9)GlcNAc(2) core- oligosaccharide on the lipid carrier dolichyl diphosphate.
  • Early mannosylation steps occur on the cytoplasmic side of the endoplasmic reticulum with GDP-Man as donor, the final reactions from Man(5)GlcNAc(2)-PP-dolichol to Man(9)Glc-NAc(2)-PP-dolichol on the lumenal side use dolichyl beta-D-mannosyl phosphate.
  • ALG9 mannosyltransferase catalyzes the addition of two different alpha-1,2-mannose residues - the addition of alpha-1,2-mannose to Man(6)GlcNAc(2)-PP-dolichol (EC 2.4.1.259) and the addition of alpha- 1,2-mannose to Man(8)GlcNAc(2)-PP-dolichol (EC 2.4.1.261).
  • Formerly EC 2.4.1.130.
Cross-references
BRENDA2.4.1.259
EC2PDB2.4.1.259
ExplorEnz2.4.1.259
PRIAM enzyme-specific profiles2.4.1.259
KEGG Ligand Database for Enzyme Nomenclature2.4.1.259
IUBMB Enzyme Nomenclature2.4.1.259
IntEnz2.4.1.259
MEDLINEFind literature relating to 2.4.1.259
MetaCyc2.4.1.259
UniProtKB/Swiss-Prot
Q9FZ49, ALG9_ARATH;  Q9H6U8, ALG9_HUMAN;  Q8VDI9, ALG9_MOUSE;  
Q9P7Q9, ALG9_SCHPO;  P53868, ALG9_YEAST;  

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