ENZYME entry: EC 2.4.1.266

Accepted Name
Glucosyl-3-phosphoglycerate synthase.
Alternative Name(s)
Glucosylphosphoglycerate synthase.
GPG synthase.
Reaction catalysed
NDP-glucose + 3-phospho-D-glycerate <=> NDP + 2-O-(alpha-D-glucopyranosyl)-3-phospho-D-glycerate
Comment(s)
  • The enzyme is involved in biosynthesis of 2-O-(alpha-D- glucopyranosyl)-D-glycerate via the two-step pathway in which glucosyl-3-phosphoglycerate synthase catalyzes the conversion of GDP- glucose and 3-phospho-D-glycerate into 2-O-(alpha-D-glucopyranosyl)- 3-phospho-D-glycerate, which is then converted to 2-O-(alpha-D- glucopyranosyl)-D-glycerate by EC 3.1.3.85.
  • The activity is dependent on divalent cations (Mn(2+), Co(2+), or Mg(2+)).
  • The enzyme from Persephonella marina shows moderate flexibility on the sugar donor concerning the nucleotide moiety (UDP-glucose, ADP- glucose, GDP-glucose) but is strictly specific for glucose.
  • The enzyme is also strictly specific for 3-phospho-D-glycerate as acceptor.
  • The enzyme from Methanococcoides burtonii is strictly specific for GDP-glucose and 3-phospho-D-glycerate.
  • This enzyme catalyzes the first glucosylation step in methylglucose lipopolysaccharide biosynthesis in mycobacteria.
Cross-references
BRENDA2.4.1.266
EC2PDB2.4.1.266
ExplorEnz2.4.1.266
PRIAM enzyme-specific profiles2.4.1.266
KEGG Ligand Database for Enzyme Nomenclature2.4.1.266
IUBMB Enzyme Nomenclature2.4.1.266
IntEnz2.4.1.266
MEDLINEFind literature relating to 2.4.1.266
MetaCyc2.4.1.266
UniProtKB/Swiss-Prot
Q12XX4, GPGS_METBU;  Q7U0E1, GPGS_MYCBO;  Q73WU1, GPGS_MYCPA;  
A0R2E6, GPGS_MYCS2;  P9WMW8, GPGS_MYCTO;  P9WMW9, GPGS_MYCTU;  
C0QRQ2, GPGS_PERMH;  A9BHI9, GPGS_PETMO;  

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