ENZYME entry: EC 2.4.1.277

Accepted Name
10-deoxymethynolide desosaminyltransferase.
Alternative Name(s)
Glycosyltransferase DesVII.
Reaction catalysed
dTDP-3-dimethylamino-3,4,6-trideoxy-alpha-D-glucopyranose + 10-deoxymethynolide <=> dTDP + 10-deoxymethymycin
Comment(s)
  • DesVII is the glycosyltransferase responsible for the attachment of dTDP-D-desosamine to 10-deoxymethynolide or narbonolide during the biosynthesis of methymycin, neomethymycin, narbomycin, and pikromycin in the bacterium Streptomyces venezuelae.
  • Activity requires an additional protein partner, DesVIII.
Cross-references
BRENDA2.4.1.277
EC2PDB2.4.1.277
ExplorEnz2.4.1.277
PRIAM enzyme-specific profiles2.4.1.277
KEGG Ligand Database for Enzyme Nomenclature2.4.1.277
IUBMB Enzyme Nomenclature2.4.1.277
IntEnz2.4.1.277
MEDLINEFind literature relating to 2.4.1.277
MetaCyc2.4.1.277
UniProtKB/Swiss-Prot
Q9ZGH7, DES7_STRVZ

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