ENZYME entry: EC 2.4.1.313

Accepted Name
Protein O-mannose beta-1,3-N-acetylgalactosaminyltransferase.
Reaction catalysed
UDP-N-acetyl-alpha-D-galactosamine + 3-O-(N-acetyl-beta-D-glucosaminyl-(1->4)-alpha-D-mannosyl)-L-threonyl-[protein] <=> UDP + 3-O-(N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-alpha-D-mannosyl)-L-threonyl-[protein]
Comment(s)
  • The human protein is specific for UDP-N-acetyl-alpha-D-galactosamine as donor.
  • The enzyme is involved in the formation of a phosphorylated trisaccharide on a threonine residue of alpha-dystroglycan, an extracellular peripheral glycoprotein that acts as a receptor for extracellular matrix proteins containing laminin-G domains.
Cross-references
BRENDA2.4.1.313
EC2PDB2.4.1.313
ExplorEnz2.4.1.313
PRIAM enzyme-specific profiles2.4.1.313
KEGG Ligand Database for Enzyme Nomenclature2.4.1.313
IUBMB Enzyme Nomenclature2.4.1.313
IntEnz2.4.1.313
MEDLINEFind literature relating to 2.4.1.313
MetaCyc2.4.1.313

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