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ENZYME

ENZYME entry: EC 2.4.1.341

Accepted Name
alpha-1,2-colitosyltransferase
Reaction catalysed
beta-D-galactosyl-(1->3)-N-acetyl-D-glucosamine + GDP-beta-L-colitose <=> alpha-L-colitosyl-(1->2)-beta-D-galactosyl-(1->3)-N-acetyl-D-glucosamine + GDP + H(+)
Comment(s)
  • The enzyme, characterized from the bacterium Escherichia coli O55:H7, participates in the biosynthesis of an O-antigen.
  • The reaction involves anomeric inversion, and does not require any metal ions.
  • The enzyme is highly specific toward the acceptor, exclusively recognizing lacto-N-biose, but can accept GDP-L-fucose as the donor with almost the same activity as with GDP-beta-L-colitose.
Cross-references
BRENDA2.4.1.341
EC2PDB2.4.1.341
ExplorEnz2.4.1.341
PRIAM enzyme-specific profiles2.4.1.341
KEGG Ligand Database for Enzyme Nomenclature2.4.1.341
IUBMB Enzyme Nomenclature2.4.1.341
IntEnz2.4.1.341
MEDLINEFind literature relating to 2.4.1.341
MetaCyc2.4.1.341
Rhea expert-curated reactions2.4.1.341
UniProtKB/Swiss-Prot
Q8VQ46, WBGN_ECOLX

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