ID   2.4.1.65
DE   3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase.
AN   (Le(a))-dependent (alpha-3/4)-fucosyltransferase.
AN   Alpha-(1,3/1,4) fucosyltransferase III.
AN   Alpha-(1->4)-L-fucosyltransferase.
AN   Alpha-4-L-fucosyltransferase.
AN   Beta-acetylglucosaminylsaccharide fucosyltransferase.
AN   Blood group Lewis alpha-4-fucosyltransferase.
AN   Blood-group substance Le(a)-dependent fucosyltransferase.
AN   FucT-II.
AN   Galactoside 3(4)-L-fucosyltransferase.
AN   Guanosine diphosphofucose-beta-acetylglucosaminylsaccharide 4-alpha-L-
AN   fucosyltransferase.
AN   Guanosine diphosphofucose-glycoprotein 4-alpha-fucosyltransferase.
AN   Guanosine diphosphofucose-glycoprotein 4-alpha-L-fucosyltransferase.
AN   Lewis alpha-(1->3/4)-fucosyltransferase.
AN   Lewis blood group alpha-(1->3/4)-fucosyltransferase.
AN   Lewis FT.
AN   Lewis(Le) blood group gene-dependent alpha-(1->3/4)-L-fucosyltransferase.
CA   GDP-beta-L-fucose + beta-D-galactosyl-(1->3)-N-acetyl-D-glucosaminyl-R =
CA   GDP + beta-D-galactosyl-(1->3)-(alpha-L-fucosyl-(1->4))-N-acetyl-beta-D-
CA   glucosaminyl-R.
CC   -!- Product of the Lewis blood group gene.
CC   -!- Normally acts on a glycoconjugate where R (see CA line) is a
CC       glycoprotein or glycolipid.
CC   -!- Although it is a 4-fucosyltransferase, it has a persistent
CC       3-fucosyltransferase activity toward the glucose residue in free
CC       lactose.
CC   -!- Fucosylates on O-4 of an N-acetylglucosamine that carries a
CC       galactosyl group on O-3, unlike EC 2.4.1.152 which fucosylates on O-3
CC       of an N-acetylglucosamine that carries a galactosyl group on O-4.
CC   -!- Enzymes catalyzing the 4-alpha-fucosylation of the GlcNAc in beta-D-
CC       Gal-(1->3)-beta-GlcNAc sequences (with some activity also as 3-alpha-
CC       fucosyltransferases) are present in plants, where the function in
CC       vivo is the modification of N-glycans.
CC   -!- In addition, the fucTa gene of Helicobacter strain UA948 encodes a
CC       fucosyltransferase with both 3-alpha- and 4-alpha-fucosyltransferase
CC       activities.
DR   Q11126, FUT3_BOVIN ;  P21217, FUT3_HUMAN ;  O19058, FUT3_PANTR ;
DR   Q8HYJ5, FUT3_PONPY ;  Q8HYJ7, FUT5_GORGO ;  Q11128, FUT5_HUMAN ;
DR   Q8HYJ3, FUT5_HYLLA ;  P56433, FUT5_PANTR ;  Q8HYJ4, FUT5_PONPY ;
DR   Q8HYJ6, FUT6_GORGO ;  P51993, FUT6_HUMAN ;  P56434, FUT6_PANTR ;
DR   Q9GKU6, FUT6_PONPY ;
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