ENZYME entry: EC 2.4.1.87

Accepted Name
N-acetyllactosaminide 3-alpha-galactosyltransferase.
Alternative Name(s)
Alpha-galactosyltransferase.
Beta-D-galactosyl-N-acetylglucosaminylglycopeptide alpha-1,3- galactosyltransferase.
Galactosyltransferase.
Glucosaminylglycopeptide alpha-1,3-galactosyltransferase.
N-acetyllactosaminide alpha-1,3-galactosyltransferase.
UDP-Gal:Gal-beta-1->4GlcNAc-R alpha-1->3-galactosyltransferase.
UDP-Gal:N-acetyllactosaminide alpha-1,3-D-galactosyltransferase.
UDP-galactose-acetyllactosamine alpha-D-galactosyltransferase.
UDPgalactose:beta-D-galactosyl-beta-1,4-N-acetyl-D-glucosaminyl- glycopeptide alpha-1,3-D-galactosyltransferase.
Uridine diphosphogalactose-acetyllactosamine alpha- 1->3-galactosyltransferase.
Uridine diphosphogalactose-acetyllactosamine galactosyltransferase.
Uridine diphosphogalactose-galactosylacetylglucosaminylgalactosyl- glucosylceramide galactosyltransferase.
Reaction catalysed
UDP-alpha-D-galactose + beta-D-galactosyl-(1->4)-beta-N-acetyl-D-glucosaminyl-R <=> UDP + alpha-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-N-acetylglucosaminyl-R
Comment(s)
  • Acts on beta-galactosyl-1,4-N-acetylglucosaminyl termini on asialo- alpha(1)-acid glycoprotein and N-acetyllactosamine (beta-D- galactosyl-1,4-N-acetyl-beta-D-glucosamine), but not on 2'-fucosylated-N-acetyllactosamine.
  • The non-reducing terminal N-acetyllactosamine residues of glycoproteins can also act as acceptor.
  • Now includes EC 2.4.1.124 and EC 2.4.1.151.
Cross-references
BRENDA2.4.1.87
EC2PDB2.4.1.87
ExplorEnz2.4.1.87
PRIAM enzyme-specific profiles2.4.1.87
KEGG Ligand Database for Enzyme Nomenclature2.4.1.87
IUBMB Enzyme Nomenclature2.4.1.87
IntEnz2.4.1.87
MEDLINEFind literature relating to 2.4.1.87
MetaCyc2.4.1.87
UniProtKB/Swiss-Prot
U3KPV4, A3LT2_HUMAN;  Q3V1N9, A3LT2_MOUSE;  A0A4Z3, A3LT2_RAT;  
A1YGR5, GGTA1_ALOCA;  P14769, GGTA1_BOVIN;  Q8SQ20, GGTA1_CALJA;  
Q8HY56, GGTA1_FELCA;  Q8HYB2, GGTA1_LEMCA;  A1YGR6, GGTA1_LORTA;  
P23336, GGTA1_MOUSE;  P50127, GGTA1_PIG;  Q3L7M0, GGTA1_RAT;  
Q8SPR2, GGTA1_SAPAP;  A2AUQ7, GTA1L_MOUSE;  G3V9Q9, GTA1L_RAT;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.4.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.4.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-