ENZYME

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ENZYME entry: EC 2.4.1.92

Accepted Name

(N-acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase.

Alternative Name(s)

Asialo-GM2 synthase.

Beta-1,4N-aetylgalactosaminyltransferase.

GalNAc-T.

Ganglioside GM2 synthase.

Ganglioside GM3 acetylgalactosaminyltransferase.

GM2 synthase.

GM2/GD2-synthase.

UDP acetylgalactosamine-(N-acetylneuraminyl)-D-galactosyl-D- glucosylceramide acetylgalactosaminyltransferase.

UDP-N-acetylgalactosamine GM3 N-acetylgalactosaminyltransferase.

Uridine diphosphoacetylgalactosamine- acetylneuraminylgalactosylglucosylceramide acetylgalactosaminyltransferase.

Uridine diphosphoacetylgalactosamine-ganglioside GM3 acetylgalactosaminyltransferase.

Uridine diphosphoacetylgalactosamine-hematoside acetylgalactosaminyltransferase.

Reaction catalysed

UDP-N-acetyl-D-galactosamine + 1-O-(O-(N-acetyl-alpha-neuraminosyl)-(2->3)-O-beta-D-galactopyranosyl-(1->4)-beta-D-glucopyranosyl)-ceramide <=> UDP + 1-O-(O-2-(acetylamino)-2-deoxy-beta-D-galactopyranosyl-(1->4)-O-(N-acetyl-alpha-neuraminosyl-(2->3))-O-beta-D-galactopyranosyl-(1->4)-beta-D-glucopyranosyl)-ceramide

Comment(s)

Catalyzes the formation of the gangliosides (i.e. sialic-acid- containing glycosphingolipids) GM2, GD2 and SM2 from GM3, GD3 and SM3, respectively.
Asialo-GM3 and lactosylceramide are also substrates, but glycoproteins and oligosaccharides are not substrates.

Cross-references

BRENDA

2.4.1.92

EC2PDB

2.4.1.92

ExplorEnz

2.4.1.92

PRIAM enzyme-specific profiles

2.4.1.92

KEGG Ligand Database for Enzyme Nomenclature

2.4.1.92

IUBMB Enzyme Nomenclature