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ENZYME entry: EC 2.4.1.92

Accepted Name
(N-acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase.
Alternative Name(s)
Asialo-GM2 synthase.
Beta-1,4N-aetylgalactosaminyltransferase.
GalNAc-T.
Ganglioside GM2 synthase.
Ganglioside GM3 acetylgalactosaminyltransferase.
GM2 synthase.
GM2/GD2-synthase.
UDP acetylgalactosamine-(N-acetylneuraminyl)-D-galactosyl-D- glucosylceramide acetylgalactosaminyltransferase.
UDP-N-acetylgalactosamine GM3 N-acetylgalactosaminyltransferase.
Uridine diphosphoacetylgalactosamine- acetylneuraminylgalactosylglucosylceramide acetylgalactosaminyltransferase.
Uridine diphosphoacetylgalactosamine-ganglioside GM3 acetylgalactosaminyltransferase.
Uridine diphosphoacetylgalactosamine-hematoside acetylgalactosaminyltransferase.
Reaction catalysed
UDP-N-acetyl-alpha-D-galactosamine + O-(N-acetyl-alpha-neuraminyl)-(2->3)-O-beta-D-galactopyranosyl-(1->4)-beta-D-glucopyranosyl-(1<->1)-ceramide <=> UDP + O-2-(acetylamino)-2-deoxy-beta-D-galactopyranosyl-(1->4)-O-(N-acetyl-alpha-neuraminyl-(2->3))-O-beta-D-galactopyranosyl-(1->4)-beta-D-glucopyranosyl-(1<->1)-ceramide
Comment(s)
  • Catalyzes the formation of the gangliosides (i.e. sialic-acid- containing glycosphingolipids) GM2, GD2 and SM2 from GM3, GD3 and SM3, respectively.
  • Asialo-GM3 and lactosylceramide are also substrates, but glycoproteins and oligosaccharides are not substrates.
Cross-references
BRENDA2.4.1.92
EC2PDB2.4.1.92
ExplorEnz2.4.1.92
PRIAM enzyme-specific profiles2.4.1.92
KEGG Ligand Database for Enzyme Nomenclature2.4.1.92
IUBMB Enzyme Nomenclature2.4.1.92
IntEnz2.4.1.92
MEDLINEFind literature relating to 2.4.1.92
MetaCyc2.4.1.92
UniProtKB/Swiss-Prot
Q00973, B4GN1_HUMAN;  Q09200, B4GN1_MOUSE;  Q10468, B4GN1_RAT;  

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All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.4.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.4.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-