ENZYME entry: EC 2.4.2.19
| Accepted Name |
|---|
| Nicotinate-nucleotide diphosphorylase (carboxylating).
|
| Alternative Name(s) |
|---|
| Nicotinate-nucleotide pyrophosphorylase (carboxylating). |
| Quinolinate phosphoribosyltransferase (decarboxylating). |
| Reaction catalysed |
|---|
| Beta-nicotinate D-ribonucleotide + diphosphate + CO(2) <=> pyridine-2,3-dicarboxylate + 5-phospho-alpha-D-ribose 1-diphosphate |
| Comment(s) |
|---|
- The reaction is catalyzed in the opposite direction.
- Since quinolinate is synthesized from L-tryptophan in eukaryotes,
but from L-aspartate in some prokaryotes, this is the first NAD(+)
biosynthesis enzyme shared by both eukaryotes and prokaryotes.
|
| Cross-references |
|---|
| BRENDA | 2.4.2.19 |
| EC2PDB | 2.4.2.19 |
| ExplorEnz | 2.4.2.19 |
| PRIAM enzyme-specific profiles | 2.4.2.19 |
| KEGG Ligand Database for Enzyme Nomenclature | 2.4.2.19 |
| IUBMB Enzyme Nomenclature | 2.4.2.19 |
| IntEnz | 2.4.2.19 |
| MEDLINE | Find literature relating to 2.4.2.19 |
| MetaCyc | 2.4.2.19 |
| UniProtKB/Swiss-Prot |
| O28439, NADC_ARCFU; | P39666, NADC_BACSU; | Q3T063, NADC_BOVIN; |
| Q75JX0, NADC_DICDI; | P30011, NADC_ECOLI; | Q9ZJN2, NADC_HELPJ; |
| O25909, NADC_HELPY; | Q15274, NADC_HUMAN; | Q57916, NADC_METJA; |
| O27860, NADC_METTH; | Q91X91, NADC_MOUSE; | P46714, NADC_MYCLE; |
| O06594, NADC_MYCTU; | A7SG73, NADC_NEMVE; | P30819, NADC_PSEAE; |
| Q5I0M2, NADC_RAT; | P77938, NADC_RHORU; | P30012, NADC_SALTY; |
| P74301, NADC_SYNY3; | P43619, NADC_YEAST; |
|
View entry in original ENZYME format
View entry in raw text format (no links)
All UniProtKB/Swiss-Prot
entries referenced
in this entry, with possibility to download in different formats, align etc.
All
ENZYME /
UniProtKB/Swiss-Prot entries corresponding to 2.4.2.-
All
ENZYME /
UniProtKB/Swiss-Prot entries corresponding to 2.4.-.-
All
ENZYME /
UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-