ENZYME entry: EC 2.4.2.19

Accepted Name
Nicotinate-nucleotide diphosphorylase (carboxylating).
Alternative Name(s)
Nicotinate-nucleotide pyrophosphorylase (carboxylating).
Quinolinate phosphoribosyltransferase (decarboxylating).
Reaction catalysed
Beta-nicotinate D-ribonucleotide + diphosphate + CO(2) <=> pyridine-2,3-dicarboxylate + 5-phospho-alpha-D-ribose 1-diphosphate
Comment(s)
  • The reaction is catalyzed in the opposite direction.
  • Since quinolinate is synthesized from L-tryptophan in eukaryotes, but from L-aspartate in some prokaryotes, this is the first NAD(+) biosynthesis enzyme shared by both eukaryotes and prokaryotes.
Cross-references
BRENDA2.4.2.19
EC2PDB2.4.2.19
ExplorEnz2.4.2.19
PRIAM enzyme-specific profiles2.4.2.19
KEGG Ligand Database for Enzyme Nomenclature2.4.2.19
IUBMB Enzyme Nomenclature2.4.2.19
IntEnz2.4.2.19
MEDLINEFind literature relating to 2.4.2.19
MetaCyc2.4.2.19
UniProtKB/Swiss-Prot
Q9ZU32, NADC_ARATH;  O28439, NADC_ARCFU;  P39666, NADC_BACSU;  
Q3T063, NADC_BOVIN;  Q75JX0, NADC_DICDI;  P30011, NADC_ECOLI;  
Q9ZJN2, NADC_HELPJ;  O25909, NADC_HELPY;  Q15274, NADC_HUMAN;  
Q57916, NADC_METJA;  O27860, NADC_METTH;  Q91X91, NADC_MOUSE;  
P46714, NADC_MYCLE;  P9WJJ6, NADC_MYCTO;  P9WJJ7, NADC_MYCTU;  
A7SG73, NADC_NEMVE;  Q0IZS0, NADC_ORYSJ;  P30819, NADC_PSEAE;  
Q5I0M2, NADC_RAT;  P77938, NADC_RHORU;  P30012, NADC_SALTY;  
P74301, NADC_SYNY3;  P43619, NADC_YEAST;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.4.2.-
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