ENZYME entry: EC 2.4.2.2

Accepted Name
Pyrimidine-nucleoside phosphorylase.
Alternative Name(s)
Py-NPase.
Reaction catalysed
  • Uridine + phosphate <=> uracil + alpha-D-ribose 1-phosphate
  • Thymidine + phosphate <=> thymine + 2-deoxy-alpha-D-ribose 1-phosphate
  • 2'-deoxyuridine + phosphate <=> uracil + 2-deoxy-alpha-D-ribose 1-phosphate
Comment(s)
  • Unlike EC 2.4.2.3, and EC 2.4.2.4, this enzyme can accept both the ribonucleoside uridine and the 2'-deoxyribonucleosides 2'-deoxyuridine and thymidine.
  • The reaction is reversible, and the enzyme does not distinguish between alpha-D-ribose 1-phosphate and 2-deoxy-alpha-D-ribose 1-phosphate in the synthetic direction.
  • Formerly EC 2.4.2.23.
Cross-references
PROSITEPDOC00557
BRENDA2.4.2.2
EC2PDB2.4.2.2
ExplorEnz2.4.2.2
PRIAM enzyme-specific profiles2.4.2.2
KEGG Ligand Database for Enzyme Nomenclature2.4.2.2
IUBMB Enzyme Nomenclature2.4.2.2
IntEnz2.4.2.2
MEDLINEFind literature relating to 2.4.2.2
MetaCyc2.4.2.2
UniProtKB/Swiss-Prot
P39142, PDP_BACSU;  P77836, PDP_GEOSE;  Q2FEZ3, PDP_STAA3;  
Q2FWC1, PDP_STAA8;  Q2YUL7, PDP_STAAB;  Q5HE64, PDP_STAAC;  
Q99SC3, PDP_STAAM;  Q7A4D0, PDP_STAAN;  Q6GET9, PDP_STAAR;  
Q6G7H4, PDP_STAAS;  Q8NVF6, PDP_STAAW;  Q5HM85, PDP_STAEQ;  
Q8CNH8, PDP_STAES;  Q4L818, PDP_STAHJ;  

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